Comment on "Differential rescue of light- and food-entrainable circadian rhythms"

Ralph E. Mistlberger, Shin Yamazaki, Julie S. Pendergast, Glenn J. Landry, Toru Takumi, Wataru Nakamura

Research output: Contribution to journalComment/debate

19 Scopus citations


Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

Original languageEnglish (US)
Pages (from-to)675a
Issue number5902
StatePublished - Oct 31 2008


ASJC Scopus subject areas

  • General

Cite this

Mistlberger, R. E., Yamazaki, S., Pendergast, J. S., Landry, G. J., Takumi, T., & Nakamura, W. (2008). Comment on "Differential rescue of light- and food-entrainable circadian rhythms". Science, 322(5902), 675a.