Comment on "Differential rescue of light- and food-entrainable circadian rhythms"

Ralph E. Mistlberger, Shin Yamazaki, Julie S. Pendergast, Glenn J. Landry, Toru Takumi, Wataru Nakamura

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

Original languageEnglish (US)
JournalScience
Volume322
Issue number5902
DOIs
StatePublished - Oct 31 2008

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Circadian Rhythm
Light
Food
Hypothalamus
Weight Loss
Morbidity
Mutation

ASJC Scopus subject areas

  • General

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Mistlberger, R. E., Yamazaki, S., Pendergast, J. S., Landry, G. J., Takumi, T., & Nakamura, W. (2008). Comment on "Differential rescue of light- and food-entrainable circadian rhythms". Science, 322(5902). https://doi.org/10.1126/science.1161284

Comment on "Differential rescue of light- and food-entrainable circadian rhythms". / Mistlberger, Ralph E.; Yamazaki, Shin; Pendergast, Julie S.; Landry, Glenn J.; Takumi, Toru; Nakamura, Wataru.

In: Science, Vol. 322, No. 5902, 31.10.2008.

Research output: Contribution to journalArticle

Mistlberger, RE, Yamazaki, S, Pendergast, JS, Landry, GJ, Takumi, T & Nakamura, W 2008, 'Comment on "Differential rescue of light- and food-entrainable circadian rhythms"', Science, vol. 322, no. 5902. https://doi.org/10.1126/science.1161284
Mistlberger, Ralph E. ; Yamazaki, Shin ; Pendergast, Julie S. ; Landry, Glenn J. ; Takumi, Toru ; Nakamura, Wataru. / Comment on "Differential rescue of light- and food-entrainable circadian rhythms". In: Science. 2008 ; Vol. 322, No. 5902.
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