TY - JOUR
T1 - Commeusal bacteria shapes gut immune system through epigenetic modifications
AU - Obata, Yuuki
N1 - Publisher Copyright:
© 2014, Chiba Medical Society. All rights reserved.
PY - 2014/8/27
Y1 - 2014/8/27
N2 - The mammalian fetus is maintained under sterile conditions in the uterus. However, immediately after birth, it is exposed to a multitude of environmental microbes, some of which colonize the skin and mucosal surfaces. Particularly, the lumen of the human distal intestine harbors trillions of commensal bacteria. The colonization of bacteria contributes the promotion of the development of gut-associated lymphoid tissue, which is an inductive site for mucosal immune responses. On the other hand, aberrant immune responses to commensal bacteria cause the development of pathogenic inflammatory disorders. To avoid this risk, the intestinal mucosa has a large number of regulatory T (Treg) cells, which play a pivotal role in the containment of inflammatory responses. In this article, we introduce the role of commensal bacteria and their metabolites in the maintenance of Treg homeostasis in the colonic lamina propria.
AB - The mammalian fetus is maintained under sterile conditions in the uterus. However, immediately after birth, it is exposed to a multitude of environmental microbes, some of which colonize the skin and mucosal surfaces. Particularly, the lumen of the human distal intestine harbors trillions of commensal bacteria. The colonization of bacteria contributes the promotion of the development of gut-associated lymphoid tissue, which is an inductive site for mucosal immune responses. On the other hand, aberrant immune responses to commensal bacteria cause the development of pathogenic inflammatory disorders. To avoid this risk, the intestinal mucosa has a large number of regulatory T (Treg) cells, which play a pivotal role in the containment of inflammatory responses. In this article, we introduce the role of commensal bacteria and their metabolites in the maintenance of Treg homeostasis in the colonic lamina propria.
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M3 - Article
AN - SCOPUS:84940053083
SN - 0303-5476
VL - 90
SP - 165
EP - 170
JO - Chiba Medical Journal
JF - Chiba Medical Journal
IS - 5
ER -