@article{9d3c2fe1f5ea45b3ba626fe60fd667e8,
title = "Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection",
abstract = "The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord. Olig1 has roles in development and maturation of oligodendrocytes, evident especially within the brain. Both Olig genes contribute to neural pattern formation. Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons.",
author = "Lu, {Q. Richard} and Tao Sun and Zhimin Zhu and Nan Ma and Meritxell Garcia and Stiles, {Charles D.} and Rowitch, {David H.}",
note = "Funding Information: The authors wish to thank Qiao Zhou and David Anderson for sharing unpublished data. We are grateful to Mensheng Qui, Qiufu Ma, Stefan Thor, Dietmar Schmucker, Boris Zalc, and Andy McMahon for stimulating discussions and advice and to En Li, Amy Chen, John Lin, John Alberta, Julie Alberta, and Patricia Dahia for technical support. We also thank Tim Vartanian for help with the explant studies. Q.R.L. was supported by a National Research Service Award postdoctoral fellowship from the National Institutes of Health and a senior postdoctoral fellowship from the Charles A. King Trust Medical Foundation. T.S. thanks the National Multiple Sclerosis Society for an advanced postdoctoral fellowship. These studies were funded by a grant from the National Institute of Neurological Diseases and Stroke (NS4051 to D.H.R.), National Institute of Child Health and Development (HD24296 to C.D.S.), and the Dana-Farber/Mahoney Center for Neuro-Oncology. D.H.R. is a Kimmel Scholar, a Claudia Adams Barr Investigator, and Harry Weaver Neuroscience Scholar of the National Multiple Sclerosis Society.",
year = "2002",
month = apr,
day = "5",
doi = "10.1016/S0092-8674(02)00678-5",
language = "English (US)",
volume = "109",
pages = "75--86",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}