Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

Q. Richard Lu, Tao Sun, Zhimin Zhu, Nan Ma, Meritxell Garcia, Charles D. Stiles, David H. Rowitch

Research output: Contribution to journalArticle

733 Scopus citations

Abstract

The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord. Olig1 has roles in development and maturation of oligodendrocytes, evident especially within the brain. Both Olig genes contribute to neural pattern formation. Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons.

Original languageEnglish (US)
Pages (from-to)75-86
Number of pages12
JournalCell
Volume109
Issue number1
DOIs
StatePublished - Apr 5 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002). Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell, 109(1), 75-86. https://doi.org/10.1016/S0092-8674(02)00678-5