Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia

Carolyn A. Felix, Naomi J. Winick, Massimo Negrini, W. Paul Bowman, Carlo M. Croce, Beverly J. Lange

Research output: Contribution to journalArticle

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Abstract

Translocations at chromosomal band 11q23 characterize most de novo acute lymphoblastic leukemias (ALL) of infants, acute myeloid leukemias (AML) of infants and young children, and secondary AMLs following epipodophyllotoxin exposure. The chromosomal breakpoints at 11q23 have been cloned from isolated cases of de novo ALL and AML. Using an 859-base pair BamHI fragment of human ALL-1 complementary DNA that recognizes the genomic breakpoint region for de novo ALL and AML, we investigated two cases of secondary AML that followed etoposide-treated primary B-lineage ALL. In the first case, the translocation occurred between chromosomes 9 and 11 and the breakpoint at 11q23 lo-calized to the same 9-kilobase region of the ALL-1 gene that is disrupted in most of the de novo leukemias. In the second case the translocation was between chromosomes 11 and 19. The breakpoint occurred outside of the ALL-1 breakpoint cluster region.

Original languageEnglish (US)
Pages (from-to)2954-2956
Number of pages3
JournalCancer Research
Volume53
Issue number13
StatePublished - Jul 1 1993

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Podophyllotoxin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Genes
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 9
Genetic Translocation
Etoposide
Base Pairing
Leukemia
Complementary DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Felix, C. A., Winick, N. J., Negrini, M., Bowman, W. P., Croce, C. M., & Lange, B. J. (1993). Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. Cancer Research, 53(13), 2954-2956.

Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. / Felix, Carolyn A.; Winick, Naomi J.; Negrini, Massimo; Bowman, W. Paul; Croce, Carlo M.; Lange, Beverly J.

In: Cancer Research, Vol. 53, No. 13, 01.07.1993, p. 2954-2956.

Research output: Contribution to journalArticle

Felix, CA, Winick, NJ, Negrini, M, Bowman, WP, Croce, CM & Lange, BJ 1993, 'Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia', Cancer Research, vol. 53, no. 13, pp. 2954-2956.
Felix CA, Winick NJ, Negrini M, Bowman WP, Croce CM, Lange BJ. Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. Cancer Research. 1993 Jul 1;53(13):2954-2956.
Felix, Carolyn A. ; Winick, Naomi J. ; Negrini, Massimo ; Bowman, W. Paul ; Croce, Carlo M. ; Lange, Beverly J. / Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. In: Cancer Research. 1993 ; Vol. 53, No. 13. pp. 2954-2956.
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