Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study

Ney Alliey-Rodriguez, Tamar A. Grey, Rebecca Shafee, Jaya Padmanabhan, Neeraj Tandon, Madeline Klinger, Jonathan Spring, Lucas Coppes, Katherine Reis, Matcheri S. Keshavan, Diane Gage, Steven McCarroll, Jeffrey R. Bishop, Scot Hill, James L. Reilly, Rebekka Lencer, Brett Clementz, Peter Buckley, Shashwath Meda, Balaji NarayananDavid C. Glahn, Godfrey Pearlson, Elena I. Ivleva, Carol Tamminga, John A. Sweeney, David Curtis, Sarah Keedy, Judith A. Badner, Chunyu Liu, Elliot S. Gershon

Research output: Contribution to journalArticlepeer-review

Abstract

Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Aug 11 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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