Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study

Ney Alliey-Rodriguez; Tamar A. Grey; Rebecca Shafee; Jaya Padmanabhan; Neeraj Tandon; Madeline Klinger; Jonathan Spring; Lucas Coppes; Katherine Reis; Matcheri S. Keshavan; Diane Gage; Steven McCarroll; Jeffrey R. Bishop; Scot Hill; James L. Reilly; Rebekka Lencer; Brett Clementz; Peter Buckley; Shashwath Meda; Balaji Narayanan; David C. Glahn; Godfrey Pearlson; Elena I. Ivleva; Carol Tamminga; John A. Sweeney; David Curtis; Sarah Keedy; Judith A. Badner; Chunyu Liu; Elliot S. Gershon

doi:10.1101/175489

Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study

Ney Alliey-Rodriguez, Tamar A. Grey, Rebecca Shafee, Jaya Padmanabhan, Neeraj Tandon, Madeline Klinger, Jonathan Spring, Lucas Coppes, Katherine Reis, Matcheri S. Keshavan, Diane Gage, Steven McCarroll, Jeffrey R. Bishop, Scot Hill, James L. Reilly, Rebekka Lencer, Brett Clementz, Peter Buckley, Shashwath Meda, Balaji NarayananDavid C. Glahn, Godfrey Pearlson, Elena I. Ivleva, Carol Tamminga, John A. Sweeney, David Curtis, Sarah Keedy, Judith A. Badner, Chunyu Liu, Elliot S. Gershon

Research output: Contribution to journal › Article › peer-review

Abstract

Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.

Original language	English (US)
Journal	Unknown Journal
DOIs	https://doi.org/10.1101/175489
State	Published - Aug 11 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Immunology and Microbiology(all)
Neuroscience(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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Alliey-Rodriguez, N., Grey, T. A., Shafee, R., Padmanabhan, J., Tandon, N., Klinger, M., Spring, J., Coppes, L., Reis, K., Keshavan, M. S., Gage, D., McCarroll, S., Bishop, J. R., Hill, S., Reilly, J. L., Lencer, R., Clementz, B., Buckley, P., Meda, S., ... Gershon, E. S. (2017). Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study. Unknown Journal. https://doi.org/10.1101/175489

Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study. / Alliey-Rodriguez, Ney; Grey, Tamar A.; Shafee, Rebecca; Padmanabhan, Jaya; Tandon, Neeraj; Klinger, Madeline; Spring, Jonathan; Coppes, Lucas; Reis, Katherine; Keshavan, Matcheri S.; Gage, Diane; McCarroll, Steven; Bishop, Jeffrey R.; Hill, Scot; Reilly, James L.; Lencer, Rebekka; Clementz, Brett; Buckley, Peter; Meda, Shashwath; Narayanan, Balaji; Glahn, David C.; Pearlson, Godfrey; Ivleva, Elena I.; Tamminga, Carol; Sweeney, John A.; Curtis, David; Keedy, Sarah; Badner, Judith A.; Liu, Chunyu; Gershon, Elliot S.

In: Unknown Journal, 11.08.2017.

Research output: Contribution to journal › Article › peer-review

Alliey-Rodriguez, N, Grey, TA, Shafee, R, Padmanabhan, J, Tandon, N, Klinger, M, Spring, J, Coppes, L, Reis, K, Keshavan, MS, Gage, D, McCarroll, S, Bishop, JR, Hill, S, Reilly, JL, Lencer, R, Clementz, B, Buckley, P, Meda, S, Narayanan, B, Glahn, DC, Pearlson, G, Ivleva, EI , Tamminga, C, Sweeney, JA, Curtis, D, Keedy, S, Badner, JA, Liu, C & Gershon, ES 2017, 'Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study', Unknown Journal. https://doi.org/10.1101/175489

Alliey-Rodriguez, Ney ; Grey, Tamar A. ; Shafee, Rebecca ; Padmanabhan, Jaya ; Tandon, Neeraj ; Klinger, Madeline ; Spring, Jonathan ; Coppes, Lucas ; Reis, Katherine ; Keshavan, Matcheri S. ; Gage, Diane ; McCarroll, Steven ; Bishop, Jeffrey R. ; Hill, Scot ; Reilly, James L. ; Lencer, Rebekka ; Clementz, Brett ; Buckley, Peter ; Meda, Shashwath ; Narayanan, Balaji ; Glahn, David C. ; Pearlson, Godfrey ; Ivleva, Elena I. ; Tamminga, Carol ; Sweeney, John A. ; Curtis, David ; Keedy, Sarah ; Badner, Judith A. ; Liu, Chunyu ; Gershon, Elliot S. / Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study. In: Unknown Journal. 2017.

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abstract = "Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.",

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AU - Alliey-Rodriguez, Ney

AU - Grey, Tamar A.

AU - Shafee, Rebecca

AU - Padmanabhan, Jaya

AU - Tandon, Neeraj

AU - Klinger, Madeline

AU - Spring, Jonathan

AU - Coppes, Lucas

AU - Reis, Katherine

AU - Keshavan, Matcheri S.

AU - Gage, Diane

AU - McCarroll, Steven

AU - Bishop, Jeffrey R.

AU - Hill, Scot

AU - Reilly, James L.

AU - Lencer, Rebekka

AU - Clementz, Brett

AU - Buckley, Peter

AU - Meda, Shashwath

AU - Narayanan, Balaji

AU - Glahn, David C.

AU - Pearlson, Godfrey

AU - Ivleva, Elena I.

AU - Tamminga, Carol

AU - Sweeney, John A.

AU - Curtis, David

AU - Keedy, Sarah

AU - Badner, Judith A.

AU - Liu, Chunyu

AU - Gershon, Elliot S.

N1 - Publisher Copyright: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2017/8/11

Y1 - 2017/8/11

N2 - Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.

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