Comparative bacteriology of parenteral single-agent vs. combination therapy in salpingitis

D. L. Hemsell, M. C. Heard, B. J. Nobles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Protected devices recovered bacteria from the endometrium of 119 women with acute salpingitis prior to and after clinically successful parenteral antimicrobial therapy in a prospective, randomized clinical trial. Single-agent antimicrobial therapy in a prospective, randomized clinical trial. Single-agent therapy consisted of ceftizoxime given at two different dosing intervals. Intravenous doxycycline was also added to twice-daily ceftizoxime or cefoxitin 4 times daily. The 52% overall reduction in aerobic and anaerobic bacterial species recovered after therapy was similar for all four regimens (p=0.169). Neither more frequent dosing of ceftizoxime nor the addition of doxycycline resulted in more effective eradication of isolates. Significantly more bacteria were resistant in vitro to doxycycline than to the coadministered ceftizoxime (p<0.001) or cefoxitin (p=0.005). Doxycycline did not add sufficient antibacterial activity to warrant its intravenous administration.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalAdvances in Therapy
Volume8
Issue number1
StatePublished - 1991

Fingerprint

Ceftizoxime
Salpingitis
Bacteriology
Doxycycline
Cefoxitin
Randomized Controlled Trials
Bacteria
Therapeutics
Endometrium
Anti-Infective Agents
Intravenous Administration
Equipment and Supplies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparative bacteriology of parenteral single-agent vs. combination therapy in salpingitis. / Hemsell, D. L.; Heard, M. C.; Nobles, B. J.

In: Advances in Therapy, Vol. 8, No. 1, 1991, p. 27-35.

Research output: Contribution to journalArticle

@article{3cc1800e1d2247ebbd4f71124da06cdd,
title = "Comparative bacteriology of parenteral single-agent vs. combination therapy in salpingitis",
abstract = "Protected devices recovered bacteria from the endometrium of 119 women with acute salpingitis prior to and after clinically successful parenteral antimicrobial therapy in a prospective, randomized clinical trial. Single-agent antimicrobial therapy in a prospective, randomized clinical trial. Single-agent therapy consisted of ceftizoxime given at two different dosing intervals. Intravenous doxycycline was also added to twice-daily ceftizoxime or cefoxitin 4 times daily. The 52{\%} overall reduction in aerobic and anaerobic bacterial species recovered after therapy was similar for all four regimens (p=0.169). Neither more frequent dosing of ceftizoxime nor the addition of doxycycline resulted in more effective eradication of isolates. Significantly more bacteria were resistant in vitro to doxycycline than to the coadministered ceftizoxime (p<0.001) or cefoxitin (p=0.005). Doxycycline did not add sufficient antibacterial activity to warrant its intravenous administration.",
author = "Hemsell, {D. L.} and Heard, {M. C.} and Nobles, {B. J.}",
year = "1991",
language = "English (US)",
volume = "8",
pages = "27--35",
journal = "Advances in Therapy",
issn = "0741-238X",
publisher = "Health Communications Inc.",
number = "1",

}

TY - JOUR

T1 - Comparative bacteriology of parenteral single-agent vs. combination therapy in salpingitis

AU - Hemsell, D. L.

AU - Heard, M. C.

AU - Nobles, B. J.

PY - 1991

Y1 - 1991

N2 - Protected devices recovered bacteria from the endometrium of 119 women with acute salpingitis prior to and after clinically successful parenteral antimicrobial therapy in a prospective, randomized clinical trial. Single-agent antimicrobial therapy in a prospective, randomized clinical trial. Single-agent therapy consisted of ceftizoxime given at two different dosing intervals. Intravenous doxycycline was also added to twice-daily ceftizoxime or cefoxitin 4 times daily. The 52% overall reduction in aerobic and anaerobic bacterial species recovered after therapy was similar for all four regimens (p=0.169). Neither more frequent dosing of ceftizoxime nor the addition of doxycycline resulted in more effective eradication of isolates. Significantly more bacteria were resistant in vitro to doxycycline than to the coadministered ceftizoxime (p<0.001) or cefoxitin (p=0.005). Doxycycline did not add sufficient antibacterial activity to warrant its intravenous administration.

AB - Protected devices recovered bacteria from the endometrium of 119 women with acute salpingitis prior to and after clinically successful parenteral antimicrobial therapy in a prospective, randomized clinical trial. Single-agent antimicrobial therapy in a prospective, randomized clinical trial. Single-agent therapy consisted of ceftizoxime given at two different dosing intervals. Intravenous doxycycline was also added to twice-daily ceftizoxime or cefoxitin 4 times daily. The 52% overall reduction in aerobic and anaerobic bacterial species recovered after therapy was similar for all four regimens (p=0.169). Neither more frequent dosing of ceftizoxime nor the addition of doxycycline resulted in more effective eradication of isolates. Significantly more bacteria were resistant in vitro to doxycycline than to the coadministered ceftizoxime (p<0.001) or cefoxitin (p=0.005). Doxycycline did not add sufficient antibacterial activity to warrant its intravenous administration.

UR - http://www.scopus.com/inward/record.url?scp=0025809880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025809880&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025809880

VL - 8

SP - 27

EP - 35

JO - Advances in Therapy

JF - Advances in Therapy

SN - 0741-238X

IS - 1

ER -