Comparative RNA-seq analysis AIDS in diagnosis of a rare pediatric tumor

Lauren M. Sanders, Arun Rangaswami, Isabel Bjork, Du Linh Lam, Holly C. Beale, Ellen Towle Kephart, Ann Durbin, Katrina Learned, Rob Currie, A. Geoffrey Lyle, Jacob Pfeil, Avanthi Tayi Shah, Alex G. Lee, Stanley G. Leung, Inge H. Behroozfard, Marcus R. Breese, Jennifer Peralez, Florette K. Hazard, Norman Lacayo, Sheri L. SpuntDavid Haussler, Sofie R. Salama, E. Alejandro Sweet-Cordero, Olena M. Vaske

Research output: Contribution to journalArticlepeer-review

Abstract

Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis important. We describe a case of recurrent immature teratoma in a 10-yr-old female patient, in which comparative analysis of the RNA sequencing gene expression data from the patient's tumor was used effectively to aid in the diagnosis of gliomatosis peritonei.

Original languageEnglish (US)
Article numbera004317
JournalCold Spring Harbor Molecular Case Studies
Volume5
Issue number5
DOIs
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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