Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice

I. M. Dozmorov; I. I. Kuzin; N. I. Lutsan; G. V. Lutsenko; A. L. Prokhorova; A. M. Sapozhnikov; T. M. Andronova; V. T. Ivanov

doi:10.3109/08923979409007087

Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice

I. M. Dozmorov, I. I. Kuzin, N. I. Lutsan, G. V. Lutsenko, A. L. Prokhorova, A. M. Sapozhnikov, T. M. Andronova, V. T. Ivanov

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

Original language	English (US)
Pages (from-to)	149-163
Number of pages	15
Journal	Immunopharmacology and Immunotoxicology
Volume	16
Issue number	2
DOIs	https://doi.org/10.3109/08923979409007087
State	Published - 1994

Keywords

CM-culture medium
GMDP-glucosaminil-muramyl peptide
LDA-limiting dilution analysis
MDP-muramyl dipeptide
MP-muramyl peptide
TRP-T-cell replacing factor

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Toxicology
Pharmacology

Access to Document

10.3109/08923979409007087

Cite this

@article{2d11dd375df64060bb763732ac939c42,

title = "Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice",

abstract = "The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.",

keywords = "CM-culture medium, GMDP-glucosaminil-muramyl peptide, LDA-limiting dilution analysis, MDP-muramyl dipeptide, MP-muramyl peptide, TRP-T-cell replacing factor",

author = "Dozmorov, {I. M.} and Kuzin, {I. I.} and Lutsan, {N. I.} and Lutsenko, {G. V.} and Prokhorova, {A. L.} and Sapozhnikov, {A. M.} and Andronova, {T. M.} and Ivanov, {V. T.}",

year = "1994",

doi = "10.3109/08923979409007087",

language = "English (US)",

volume = "16",

pages = "149--163",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice

AU - Dozmorov, I. M.

AU - Kuzin, I. I.

AU - Lutsan, N. I.

AU - Lutsenko, G. V.

AU - Prokhorova, A. L.

AU - Sapozhnikov, A. M.

AU - Andronova, T. M.

AU - Ivanov, V. T.

PY - 1994

Y1 - 1994

N2 - The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

AB - The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

KW - CM-culture medium

KW - GMDP-glucosaminil-muramyl peptide

KW - LDA-limiting dilution analysis

KW - MDP-muramyl dipeptide

KW - MP-muramyl peptide

KW - TRP-T-cell replacing factor

UR - http://www.scopus.com/inward/record.url?scp=0028290185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028290185&partnerID=8YFLogxK

U2 - 10.3109/08923979409007087

DO - 10.3109/08923979409007087

M3 - Article

C2 - 8077604

AN - SCOPUS:0028290185

SN - 0892-3973

VL - 16

SP - 149

EP - 163

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 2

ER -

Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this