Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice

I. M. Dozmorov, I. I. Kuzin, N. I. Lutsan, G. V. Lutsenko, A. L. Prokhorova, A. M. Sapozhnikov, T. M. Andronova, V. T. Ivanov

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

Original languageEnglish (US)
Pages (from-to)149-163
Number of pages15
JournalImmunopharmacology and Immunotoxicology
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1994

Keywords

  • CM-culture medium
  • GMDP-glucosaminil-muramyl peptide
  • LDA-limiting dilution analysis
  • MDP-muramyl dipeptide
  • MP-muramyl peptide
  • TRP-T-cell replacing factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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    Dozmorov, I. M., Kuzin, I. I., Lutsan, N. I., Lutsenko, G. V., Prokhorova, A. L., Sapozhnikov, A. M., Andronova, T. M., & Ivanov, V. T. (1994). Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of yg and old mice. Immunopharmacology and Immunotoxicology, 16(2), 149-163. https://doi.org/10.3109/08923979409007087