Comparing proton treatment plans of pediatric brain tumors in two pencil beam scanning nozzles with different spot sizes

John C. Kralik, Liwen Xi, Timothy D. Solberg, Charles B. Simone, Liyong Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Target coverage and organ-at-risk sparing were compared for 22 pediatric patients with primary brain tumors treated using two distinct nozzles in pencil beam scanning (PBS) proton therapy. Consecutive patients treated at our institution using a PBS-dedicated nozzle (DN) were replanned using a universal nozzle (UN) beam model and the original DN plan objectives. Various cranial sites were treated among the patients to prescription doses ranging from 45 to 54 Gy. Organs at risk (OARs) evaluated were patient-dependent; 15 unique OARs were analyzed, all of which were assessed in at least 10 patients. Clinical target volume (CTV) coverage and organ sparing were compared for the two nozzles using dose-volume histogram data. Statistical analysis using a confidence-interval approach demonstrates that CTV coverage is equivalent for UN and DN plans within ± 5% equivalence bounds. In contrast, average mean and maximum doses are significantly higher for nearly all 15 OARs in the UN plans. The average median increase over all OARs and patients is approximately 1.7 Gy, with an increase in the 25%-75% of 1.0-2.3 Gy; the median increase to the pituitary gland, temporal lobes, eyes and cochleas are 1.8, 1.7, 0.7, and 2.7 Gy, respectively. The CTV dose distributions fall off slower for UN than for the DN plans; hence, normal tissue structures in close proximity to CTVs receive higher doses in UN plans than in DN plans. The higher OAR doses in the UN plans are likely due to the larger spot profile in plans created with UN beams. In light of the high rates of toxicities in pediatric patients receiving cranial irradiation and in light of selected brain tumor types having high cure rates, this study suggests the smaller DN beam profile is preferable for the advantage of reducing dose to OARs.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalJournal of Applied Clinical Medical Physics
Volume16
Issue number6
StatePublished - 2015

Fingerprint

Organs at Risk
pencil beams
Pediatrics
Brain Neoplasms
nozzles
brain
Protons
Tumors
Nozzles
Brain
tumors
Scanning
scanning
protons
organs
dosage
Therapeutics
Proton Therapy
Cranial Irradiation
Organ Size

Keywords

  • Brain
  • Pediatric
  • Pencil beam scanning
  • Treatment planning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Instrumentation

Cite this

Comparing proton treatment plans of pediatric brain tumors in two pencil beam scanning nozzles with different spot sizes. / Kralik, John C.; Xi, Liwen; Solberg, Timothy D.; Simone, Charles B.; Lin, Liyong.

In: Journal of Applied Clinical Medical Physics, Vol. 16, No. 6, 2015, p. 41-50.

Research output: Contribution to journalArticle

Kralik, John C. ; Xi, Liwen ; Solberg, Timothy D. ; Simone, Charles B. ; Lin, Liyong. / Comparing proton treatment plans of pediatric brain tumors in two pencil beam scanning nozzles with different spot sizes. In: Journal of Applied Clinical Medical Physics. 2015 ; Vol. 16, No. 6. pp. 41-50.
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