Comparing tumor response to VEGF blockade therapy using high frequency ultrasound imaging with size-selected microbubble contrast agents

Shashank Sirsi, Mark Borden, Cherry Chen, Sonia Hernandez, Jianzhong Huang, Tessa Johung, Darrell Yamashiro, Jessica Kandel, Shunichi Homma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vascular endothelial growth factors (VEGF) are key mediators in tumor growth and angiogenesis. Suppression of tumor growth by VEGF-blockade therapy is a popular approach towards improving cancer treatment. Bevacizumab (BV) is monoclonal antibody used to inhibit VEGF that has shown promise in treating several forms of cancer. However, BV is ineffective in certain forms of cancer, presumably due to unpredicted compensatory mechanisms of VEGF deficient tumors. In clinical practice, it would be advantageous to determine as early as possible whether a particular cancer would be responsive to BV treatment. In this study, we evaluate the vascular response (perfusion and molecular expression) of two human cancer cell lines (SKNEP and NGP) implanted in mice to BV therapy using high-frequency ultrasound imaging. Size-selected, lipid-coated microbubbles were used as vascular probes.

Original languageEnglish (US)
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages116-119
Number of pages4
DOIs
Publication statusPublished - Dec 1 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Other

Other2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

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Keywords

  • BV
  • microbubble
  • molecular imaging
  • neuroblastoma
  • perfusion
  • Wilms tumor

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sirsi, S., Borden, M., Chen, C., Hernandez, S., Huang, J., Johung, T., ... Homma, S. (2010). Comparing tumor response to VEGF blockade therapy using high frequency ultrasound imaging with size-selected microbubble contrast agents. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 116-119). [5935801] https://doi.org/10.1109/ULTSYM.2010.5935801