Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases.

A. A. De Salles, M. Hariz, C. L. Bajada, S. Goetsch, T. Bergenheim, M. Selch, F. E. Holly, T. Solberg, D. P. Becker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study evaluates the treatment of intracerebral brain metastases with single dose stereotactic radiosurgery in comparison to stereotactic fractionated radiotherapy (SFR). Twenty six patients with 41 lesions were evaluated. Thirty four lesions in 19 patients were treated with radiosurgery, and 7 lesions in 7 patients were treated with SFR. The radiosurgery group was treated with an average number of isocenters of 1.4, and an average of 9 arcs. The average dose was 2140 cGy delivered to the 70% isodose line. The average volume of the lesions was 5.22 cc. The SFR group lesions received a mean dose to the indicated area delivered by 4 to 6 coplanar fields. The dose was 600 cGy per fraction, 2 to 3 fractions were given. The average volume of the treated lesions was 21.2 cc. Follow-up extended from 2-18 months. Twenty five lesions of the radiosurgery group had image follow-up. The overall local control was seen in 92% of the patients. Six lesions of the SFR group had image follow-up, the local control was 83%. The small number in each group, the non-randomized nature of the study, and the relatively short follow-up preclude a definitive conclusion. SFR may be the method of choice for large lesions surrounded by significant edema. The delivery of the dose in large fractions may obviate the transient acute reactions seen when radiosurgical dose is delivered to large lesions surrounded by edema. However, both forms of therapy have proven to be effective in the control of brain metastases.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalActa Neurochirurgica, Supplement
Volume58
StatePublished - 1993

Fingerprint

Radiosurgery
Radiotherapy
Radiation
Neoplasm Metastasis
Brain
Edema
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

De Salles, A. A., Hariz, M., Bajada, C. L., Goetsch, S., Bergenheim, T., Selch, M., ... Becker, D. P. (1993). Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases. Acta Neurochirurgica, Supplement, 58, 115-118.

Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases. / De Salles, A. A.; Hariz, M.; Bajada, C. L.; Goetsch, S.; Bergenheim, T.; Selch, M.; Holly, F. E.; Solberg, T.; Becker, D. P.

In: Acta Neurochirurgica, Supplement, Vol. 58, 1993, p. 115-118.

Research output: Contribution to journalArticle

De Salles, AA, Hariz, M, Bajada, CL, Goetsch, S, Bergenheim, T, Selch, M, Holly, FE, Solberg, T & Becker, DP 1993, 'Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases.', Acta Neurochirurgica, Supplement, vol. 58, pp. 115-118.
De Salles, A. A. ; Hariz, M. ; Bajada, C. L. ; Goetsch, S. ; Bergenheim, T. ; Selch, M. ; Holly, F. E. ; Solberg, T. ; Becker, D. P. / Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases. In: Acta Neurochirurgica, Supplement. 1993 ; Vol. 58. pp. 115-118.
@article{1b839e58f7764bc9b6a985bbca448405,
title = "Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases.",
abstract = "This study evaluates the treatment of intracerebral brain metastases with single dose stereotactic radiosurgery in comparison to stereotactic fractionated radiotherapy (SFR). Twenty six patients with 41 lesions were evaluated. Thirty four lesions in 19 patients were treated with radiosurgery, and 7 lesions in 7 patients were treated with SFR. The radiosurgery group was treated with an average number of isocenters of 1.4, and an average of 9 arcs. The average dose was 2140 cGy delivered to the 70{\%} isodose line. The average volume of the lesions was 5.22 cc. The SFR group lesions received a mean dose to the indicated area delivered by 4 to 6 coplanar fields. The dose was 600 cGy per fraction, 2 to 3 fractions were given. The average volume of the treated lesions was 21.2 cc. Follow-up extended from 2-18 months. Twenty five lesions of the radiosurgery group had image follow-up. The overall local control was seen in 92{\%} of the patients. Six lesions of the SFR group had image follow-up, the local control was 83{\%}. The small number in each group, the non-randomized nature of the study, and the relatively short follow-up preclude a definitive conclusion. SFR may be the method of choice for large lesions surrounded by significant edema. The delivery of the dose in large fractions may obviate the transient acute reactions seen when radiosurgical dose is delivered to large lesions surrounded by edema. However, both forms of therapy have proven to be effective in the control of brain metastases.",
author = "{De Salles}, {A. A.} and M. Hariz and Bajada, {C. L.} and S. Goetsch and T. Bergenheim and M. Selch and Holly, {F. E.} and T. Solberg and Becker, {D. P.}",
year = "1993",
language = "English (US)",
volume = "58",
pages = "115--118",
journal = "Acta Neurochirurgica, Supplement",
issn = "0065-1419",
publisher = "Springer Wien",

}

TY - JOUR

T1 - Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases.

AU - De Salles, A. A.

AU - Hariz, M.

AU - Bajada, C. L.

AU - Goetsch, S.

AU - Bergenheim, T.

AU - Selch, M.

AU - Holly, F. E.

AU - Solberg, T.

AU - Becker, D. P.

PY - 1993

Y1 - 1993

N2 - This study evaluates the treatment of intracerebral brain metastases with single dose stereotactic radiosurgery in comparison to stereotactic fractionated radiotherapy (SFR). Twenty six patients with 41 lesions were evaluated. Thirty four lesions in 19 patients were treated with radiosurgery, and 7 lesions in 7 patients were treated with SFR. The radiosurgery group was treated with an average number of isocenters of 1.4, and an average of 9 arcs. The average dose was 2140 cGy delivered to the 70% isodose line. The average volume of the lesions was 5.22 cc. The SFR group lesions received a mean dose to the indicated area delivered by 4 to 6 coplanar fields. The dose was 600 cGy per fraction, 2 to 3 fractions were given. The average volume of the treated lesions was 21.2 cc. Follow-up extended from 2-18 months. Twenty five lesions of the radiosurgery group had image follow-up. The overall local control was seen in 92% of the patients. Six lesions of the SFR group had image follow-up, the local control was 83%. The small number in each group, the non-randomized nature of the study, and the relatively short follow-up preclude a definitive conclusion. SFR may be the method of choice for large lesions surrounded by significant edema. The delivery of the dose in large fractions may obviate the transient acute reactions seen when radiosurgical dose is delivered to large lesions surrounded by edema. However, both forms of therapy have proven to be effective in the control of brain metastases.

AB - This study evaluates the treatment of intracerebral brain metastases with single dose stereotactic radiosurgery in comparison to stereotactic fractionated radiotherapy (SFR). Twenty six patients with 41 lesions were evaluated. Thirty four lesions in 19 patients were treated with radiosurgery, and 7 lesions in 7 patients were treated with SFR. The radiosurgery group was treated with an average number of isocenters of 1.4, and an average of 9 arcs. The average dose was 2140 cGy delivered to the 70% isodose line. The average volume of the lesions was 5.22 cc. The SFR group lesions received a mean dose to the indicated area delivered by 4 to 6 coplanar fields. The dose was 600 cGy per fraction, 2 to 3 fractions were given. The average volume of the treated lesions was 21.2 cc. Follow-up extended from 2-18 months. Twenty five lesions of the radiosurgery group had image follow-up. The overall local control was seen in 92% of the patients. Six lesions of the SFR group had image follow-up, the local control was 83%. The small number in each group, the non-randomized nature of the study, and the relatively short follow-up preclude a definitive conclusion. SFR may be the method of choice for large lesions surrounded by significant edema. The delivery of the dose in large fractions may obviate the transient acute reactions seen when radiosurgical dose is delivered to large lesions surrounded by edema. However, both forms of therapy have proven to be effective in the control of brain metastases.

UR - http://www.scopus.com/inward/record.url?scp=0027735758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027735758&partnerID=8YFLogxK

M3 - Article

C2 - 8109272

AN - SCOPUS:0027735758

VL - 58

SP - 115

EP - 118

JO - Acta Neurochirurgica, Supplement

JF - Acta Neurochirurgica, Supplement

SN - 0065-1419

ER -