Comparison of Adipose Distribution Indices with Gold Standard Body Composition Assessments in the EMPA-REG H2H SU Trial: A Body Composition Sub-Study

Ian J Neeland, Darren K McGuire, Björn Eliasson, Martin Ridderstråle, Cordula Zeller, Hans J. Woerle, Uli C. Broedl, Odd Erik Johansen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Introduction: Excess adiposity contributes to cardiometabolic disease. Although adipose depots can be measured using imaging, implementation remains limited in practice. Data comparing surrogate indices of total and visceral adiposity with gold standard measurements in the context of a clinical trial population are lacking. We explored the relationships between adipose distribution indices and imaging assessments of body composition using baseline data from the EMPA-REG H2H SU™ trial. Methods: 118 participants from the Phase III trial of empagliflozin 25 mg vs. glimepiride 1–4 mg enrolled in a dedicated sub-study underwent assessment of total fat and fat-free mass by dual x-ray absorptiometry (n = 93) and abdominal visceral (VAT) and subcutaneous adipose tissue by magnetic resonance imaging (n = 99). Correlations with waist circumference (WC), estimated total body fat (eTBF), index of central obesity (ICO), and visceral adiposity index (VAI) were assessed. Results: eTBF was highly representative of total body fat (Spearman’s ρ = 0.73, P 

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalDiabetes Therapy
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2015

Keywords

  • Body fat distribution
  • Empagliflozin
  • Obesity
  • Sodium glucose co-transporter 2 inhibitor
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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