Comparison of aldolase isozymes in placenta, HeLa cells, and human fibroblast cultures

R. Gliksman, N. K. Ghosh, R. P. Cox

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Abstract

The aldolase specific activity of the human carcinoma cell line, HeLa, against fructose 1,6-diphosphate as substrate is 4- to 5-fold greater than the specific activity of diploid human fibroblast cultures derived from skin and lung. HeLa aldolase isozyme is predominantly the A type and its substrate preferences resemble human placenta. These findings provide further support for the oncofetal enzyme constitution of HeLa cells.

Original languageEnglish (US)
Pages (from-to)416-419
Number of pages4
JournalEnzyme
Volume22
Issue number6
DOIs
StatePublished - Jan 1 1977

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ASJC Scopus subject areas

  • Biochemistry

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