Comparison of breast and abdominal adipose tissue mesenchymal stromal/stem cells in support of proliferation of breast cancer cells

Jaehyup Kim, Leah E. Escalante, Bridget A. Dollar, Summer E. Hanson, Peiman Hematti

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In this study, we compared MSCs from breast and abdominal tissue in terms of their expression of genes deemed important in the support of breast cancer growth and their effect on gene profile of macrophages after coculture. In addition, we investigated the role of MSCs, alone or in combination with macrophages, on proliferation of breast cancer cell lines. Our results show that MSCs derived from breast and abdominal adipose tissues have a comparable gene expression profile, have similar effect on gene expression of macrophages, and are comparable in supporting breast cancer cell line proliferation.

Original languageEnglish (US)
Pages (from-to)550-554
Number of pages5
JournalCancer Investigation
Volume31
Issue number8
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Keywords

  • Breast cancer
  • Immunology/immunobiology
  • Macrophages
  • Mesenchymal stromal/stem cells
  • Tumor cell biology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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