In a double-blind randomized clinical trial co-trimazine was compared with co-trimoxazole in 212 patients with urinary tract infections. Co-trimazine (TMP 180 mg plus SMZ 820 mg) was given once daily and co-trimoxazole (TMP 160 mg plus SMZ 800 mg) twice daily. 14 to 21 days after the end of treatment the bacteriological cure rate was 90% for co-trimazine and 87% for co-trimoxazole. Bacterial resistance was only observed in a few cases. Side-effects occurred in 11.7% of the patients treated with co-trimazine and in 15.4% of those treated with co-trimoxazole. The side-effects were generally mild and only once in each regimen was treatment discontinued.
|Number of pages||8|
|State||Published - Jan 1 1984|
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