Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins

Margo A. Denke, Scott M Grundy

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

The effects of lauric acid (C12:0) on plasma lipids and lipoproteins were compared with the effects of palmitic acid (C16:0) and oleic acid (C18:1) in a metabolic-diet study of 14 men by using liquid-formula diets fed for 3 wk each in random order. Lauric acid was supplied in a synthetic high-lauric oil. palmitic acid was provided by palm oil and oleic acid in oleic-rich sunflower seed oil. The high-lauric oil resulted in higher concentrations of plasma total cholesterol (4.94 ± 0.75 mmol/L [x̄ ± SE]) and LDL cholesterol (3.70 ± 0.57 mmol/L) when compared with high-oleic sunflower oil (4.44 ± 0.54 and 3.31 ± 0.44 mmol/L. respectively), but did not raise total and LDL cholesterol concentrations as much as did palm oil (5.17 ± 0.65 and 3.93 0.51 mmol/L. respectively). No differences were noted in plasma triglycerides or HDL cholesterol. Lauric acid raises total and LDL cholesterol concentrations compared with oleic acid, but is not as potent for increasing cholesterol concentrations as is palmitic acid.

Original languageEnglish (US)
Pages (from-to)895-898
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume56
Issue number5
StatePublished - 1992

Fingerprint

lauric acid
dodecanoic acid
Palmitic Acid
Oleic Acid
low density lipoprotein cholesterol
palmitic acid
lipoproteins
blood lipids
LDL Cholesterol
Lipoproteins
oleic acid
palm oils
sunflower oil
Lipids
Oils
Cholesterol
cholesterol
Formulated Food
oils
diet study techniques

Keywords

  • Cholesterol-raising fatty acid
  • Lauric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. / Denke, Margo A.; Grundy, Scott M.

In: American Journal of Clinical Nutrition, Vol. 56, No. 5, 1992, p. 895-898.

Research output: Contribution to journalArticle

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