TY - JOUR
T1 - Comparison of Endotoxin Release by Different Antimicrobial Agents and the Effect on Inflammation in Experimental Escherichia coli Meningitis
AU - Friedland, Ian R.
AU - Jafari, Hamid
AU - Ehrett, Stuart
AU - Rinderknecht, Stephen
AU - Paris, Maria
AU - Coulthard, Mark
AU - Saxen, Harri
AU - Olsen, Kurt
AU - McCracken, George H.
PY - 1993/9
Y1 - 1993/9
N2 - In a rabbit Escherichia coli meningitis model, endotoxin liberation and concentrations of leukocytes, tumor necrosis factor (TNF), and lactate were compared after a single intravenous dose of cefotaxime, cefpirome, meropenem, chloramphenicol, or gentamicin. These antibiotics caused a 2- to IO-fold increase in cerebrospinal fluid concentrations of free (filterable) endotoxin within 2 h of starting treatment. By contrast, free endotoxin concentrations increased almost IOO-fold in untreated animals 4 h later as bacteria continued to multiply. An initial enhancement of inflammation in the central nervous system occurred in all treatment groups compared with untreated controls. No significant differences were observed between treatment groups except for lower TNF concentrations in chloramphenicol-treated animals. Antibiotic therapy in E. coli meningitis, irrespective of the agent used, may result in an increase in free endotoxin and enhancement of inflammation, but the amount of endotoxin liberated is considerably smaller than that shed by untreated bacteria.
AB - In a rabbit Escherichia coli meningitis model, endotoxin liberation and concentrations of leukocytes, tumor necrosis factor (TNF), and lactate were compared after a single intravenous dose of cefotaxime, cefpirome, meropenem, chloramphenicol, or gentamicin. These antibiotics caused a 2- to IO-fold increase in cerebrospinal fluid concentrations of free (filterable) endotoxin within 2 h of starting treatment. By contrast, free endotoxin concentrations increased almost IOO-fold in untreated animals 4 h later as bacteria continued to multiply. An initial enhancement of inflammation in the central nervous system occurred in all treatment groups compared with untreated controls. No significant differences were observed between treatment groups except for lower TNF concentrations in chloramphenicol-treated animals. Antibiotic therapy in E. coli meningitis, irrespective of the agent used, may result in an increase in free endotoxin and enhancement of inflammation, but the amount of endotoxin liberated is considerably smaller than that shed by untreated bacteria.
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U2 - 10.1093/infdis/168.3.657
DO - 10.1093/infdis/168.3.657
M3 - Article
C2 - 8354907
AN - SCOPUS:0027272457
SN - 0022-1899
VL - 168
SP - 657
EP - 662
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -