Comparison of glucose metabolism and cerebral blood flow during cortical motor activation

M. Hallett, T. Zeffiro, R. M. Dubinsky, S. M. Bierner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Regions of cerebral cortex activated in normal subjects making simple, repetitive, voluntary wrist movements were studied with positron emission tomography (PET). The regional cerebral metabolic rate of glucose utilization was studied with 2 [18F]fluoro-2-deoxy-D-glucose (FDG), and regional cerebral blood flow was studied with 15O-labeled water. No significant activation was found with the cerebral metabolic rate studies. Studies of regional cerebral blood flow showed significant activation of the contralateral sensorimotor cortex region of 42%, of the ipsilateral sensorimotor cortex region of 19%, and of the medial frontal cortex of 30% compared with the resting state. Increases in blood flow in the contralateral sensorimotor cortex and medial frontal cortex were visible on every activated scan. Measurement of regional cerebral blood flow seems to be more sensitive than regional cerebral metabolic rate of glucose utilization for studying cortical activation with voluntary movement.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Neuroimaging
Volume4
Issue number1
StatePublished - 1994

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Frontal Lobe
Glucose
Fluorodeoxyglucose F18
Wrist
Positron-Emission Tomography
Cerebral Cortex
Water
Sensorimotor Cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Hallett, M., Zeffiro, T., Dubinsky, R. M., & Bierner, S. M. (1994). Comparison of glucose metabolism and cerebral blood flow during cortical motor activation. Journal of Neuroimaging, 4(1), 1-5.

Comparison of glucose metabolism and cerebral blood flow during cortical motor activation. / Hallett, M.; Zeffiro, T.; Dubinsky, R. M.; Bierner, S. M.

In: Journal of Neuroimaging, Vol. 4, No. 1, 1994, p. 1-5.

Research output: Contribution to journalArticle

Hallett, M, Zeffiro, T, Dubinsky, RM & Bierner, SM 1994, 'Comparison of glucose metabolism and cerebral blood flow during cortical motor activation', Journal of Neuroimaging, vol. 4, no. 1, pp. 1-5.
Hallett, M. ; Zeffiro, T. ; Dubinsky, R. M. ; Bierner, S. M. / Comparison of glucose metabolism and cerebral blood flow during cortical motor activation. In: Journal of Neuroimaging. 1994 ; Vol. 4, No. 1. pp. 1-5.
@article{9abb536b682e4dedbe70af8908a11082,
title = "Comparison of glucose metabolism and cerebral blood flow during cortical motor activation",
abstract = "Regions of cerebral cortex activated in normal subjects making simple, repetitive, voluntary wrist movements were studied with positron emission tomography (PET). The regional cerebral metabolic rate of glucose utilization was studied with 2 [18F]fluoro-2-deoxy-D-glucose (FDG), and regional cerebral blood flow was studied with 15O-labeled water. No significant activation was found with the cerebral metabolic rate studies. Studies of regional cerebral blood flow showed significant activation of the contralateral sensorimotor cortex region of 42{\%}, of the ipsilateral sensorimotor cortex region of 19{\%}, and of the medial frontal cortex of 30{\%} compared with the resting state. Increases in blood flow in the contralateral sensorimotor cortex and medial frontal cortex were visible on every activated scan. Measurement of regional cerebral blood flow seems to be more sensitive than regional cerebral metabolic rate of glucose utilization for studying cortical activation with voluntary movement.",
author = "M. Hallett and T. Zeffiro and Dubinsky, {R. M.} and Bierner, {S. M.}",
year = "1994",
language = "English (US)",
volume = "4",
pages = "1--5",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Comparison of glucose metabolism and cerebral blood flow during cortical motor activation

AU - Hallett, M.

AU - Zeffiro, T.

AU - Dubinsky, R. M.

AU - Bierner, S. M.

PY - 1994

Y1 - 1994

N2 - Regions of cerebral cortex activated in normal subjects making simple, repetitive, voluntary wrist movements were studied with positron emission tomography (PET). The regional cerebral metabolic rate of glucose utilization was studied with 2 [18F]fluoro-2-deoxy-D-glucose (FDG), and regional cerebral blood flow was studied with 15O-labeled water. No significant activation was found with the cerebral metabolic rate studies. Studies of regional cerebral blood flow showed significant activation of the contralateral sensorimotor cortex region of 42%, of the ipsilateral sensorimotor cortex region of 19%, and of the medial frontal cortex of 30% compared with the resting state. Increases in blood flow in the contralateral sensorimotor cortex and medial frontal cortex were visible on every activated scan. Measurement of regional cerebral blood flow seems to be more sensitive than regional cerebral metabolic rate of glucose utilization for studying cortical activation with voluntary movement.

AB - Regions of cerebral cortex activated in normal subjects making simple, repetitive, voluntary wrist movements were studied with positron emission tomography (PET). The regional cerebral metabolic rate of glucose utilization was studied with 2 [18F]fluoro-2-deoxy-D-glucose (FDG), and regional cerebral blood flow was studied with 15O-labeled water. No significant activation was found with the cerebral metabolic rate studies. Studies of regional cerebral blood flow showed significant activation of the contralateral sensorimotor cortex region of 42%, of the ipsilateral sensorimotor cortex region of 19%, and of the medial frontal cortex of 30% compared with the resting state. Increases in blood flow in the contralateral sensorimotor cortex and medial frontal cortex were visible on every activated scan. Measurement of regional cerebral blood flow seems to be more sensitive than regional cerebral metabolic rate of glucose utilization for studying cortical activation with voluntary movement.

UR - http://www.scopus.com/inward/record.url?scp=0028107489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028107489&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 1

EP - 5

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 1

ER -