Abstract
Since the inception of allogeneic blood transfusion, the search for an alternative to the use of stored packed red blood cells has been underway. Over the last 10 years, modified hemoglobin solutions in the form of hemoglobin-based oxygen carriers (HBOCs) have made significant strides toward becoming clinically available and useful. Although HBOCs are not yet ready for regular use in the clinical arena, this may change in the near future as HBOC products continue to improve and as the elucidation of the mechanisms of any adverse effects becomes clearer. In the mean time, we must further the development of alternative strategies for the "hemoglobin bridge" so desperately needed by many critically ill patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 303-310 |
| Number of pages | 8 |
| Journal | Critical Care Clinics |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2009 |
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Keywords
- Alternatives to transfusion
- Hemoglobin based oxygen carrier
- Military transfusion
- Packed red blood cells
- Transfusion
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Comparison of Hemoglobin-based Oxygen Carriers to Stored Human Red Blood Cells. / Eastman, Alexander L.; Minei, Joseph P.
In: Critical Care Clinics, Vol. 25, No. 2, 04.2009, p. 303-310.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of Hemoglobin-based Oxygen Carriers to Stored Human Red Blood Cells
AU - Eastman, Alexander L.
AU - Minei, Joseph P.
PY - 2009/4
Y1 - 2009/4
N2 - Since the inception of allogeneic blood transfusion, the search for an alternative to the use of stored packed red blood cells has been underway. Over the last 10 years, modified hemoglobin solutions in the form of hemoglobin-based oxygen carriers (HBOCs) have made significant strides toward becoming clinically available and useful. Although HBOCs are not yet ready for regular use in the clinical arena, this may change in the near future as HBOC products continue to improve and as the elucidation of the mechanisms of any adverse effects becomes clearer. In the mean time, we must further the development of alternative strategies for the "hemoglobin bridge" so desperately needed by many critically ill patients.
AB - Since the inception of allogeneic blood transfusion, the search for an alternative to the use of stored packed red blood cells has been underway. Over the last 10 years, modified hemoglobin solutions in the form of hemoglobin-based oxygen carriers (HBOCs) have made significant strides toward becoming clinically available and useful. Although HBOCs are not yet ready for regular use in the clinical arena, this may change in the near future as HBOC products continue to improve and as the elucidation of the mechanisms of any adverse effects becomes clearer. In the mean time, we must further the development of alternative strategies for the "hemoglobin bridge" so desperately needed by many critically ill patients.
KW - Alternatives to transfusion
KW - Hemoglobin based oxygen carrier
KW - Military transfusion
KW - Packed red blood cells
KW - Transfusion
UR - http://www.scopus.com/inward/record.url?scp=63049127060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63049127060&partnerID=8YFLogxK
U2 - 10.1016/j.ccc.2008.12.009
DO - 10.1016/j.ccc.2008.12.009
M3 - Article
C2 - 19341910
AN - SCOPUS:63049127060
VL - 25
SP - 303
EP - 310
JO - Critical Care Clinics
JF - Critical Care Clinics
SN - 0749-0704
IS - 2
ER -