Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia

Claudia L. Werner, William F. Griffith, Raheela Ashfaq, Diana Gossett, Edward Wilkinson, Stephen Raab, Shabbir Bambot, David Mongin, Mark Faupel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE. This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. MATERIALS AND METHODS. Each of 113 subjects underwent spectroscopy, thin-layer cytology, HPV testing, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies. RESULTS. Pap + HPV and Pap + CS achieved equivalent sensitivities (95%) for high-grade lesions, with both detecting 17 of 18 histology confirmed cervical intraepithelial neoplasia (CIN) 2+ lesions. Pap + HPV had a specificity of only 27.4% compared with 65.5% for Pap + CS (p < .0001). CONCLUSIONS. Spectroscopic interrogation of the cervix is equally sensitive and 2-fold more specific than HPV testing when combined with cervical cytology for identifying high-grade cervical neoplasia.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalJournal of Lower Genital Tract Disease
Volume11
Issue number2
DOIs
StatePublished - Apr 2007

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Papillomaviridae
Cell Biology
Spectrum Analysis
Colposcopy
Neoplasms
Cervical Intraepithelial Neoplasia
Curettage
Cervix Uteri
Histology
Biopsy
Sensitivity and Specificity
Population

Keywords

  • Cervical neoplasia
  • HPV testing
  • Spectroscopy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia. / Werner, Claudia L.; Griffith, William F.; Ashfaq, Raheela; Gossett, Diana; Wilkinson, Edward; Raab, Stephen; Bambot, Shabbir; Mongin, David; Faupel, Mark.

In: Journal of Lower Genital Tract Disease, Vol. 11, No. 2, 04.2007, p. 73-79.

Research output: Contribution to journalArticle

Werner, Claudia L. ; Griffith, William F. ; Ashfaq, Raheela ; Gossett, Diana ; Wilkinson, Edward ; Raab, Stephen ; Bambot, Shabbir ; Mongin, David ; Faupel, Mark. / Comparison of human papilloma virus testing and spectroscopy combined with cervical cytology for the detection of high-grade cervical neoplasia. In: Journal of Lower Genital Tract Disease. 2007 ; Vol. 11, No. 2. pp. 73-79.
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AB - OBJECTIVE. This study compared the performance of cervical cytology plus human papilloma virus testing (Pap + HPV) or cervical spectroscopy (Pap + CS) for identifying high-grade cervical neoplasia in a high-risk population of women referred for colposcopy. MATERIALS AND METHODS. Each of 113 subjects underwent spectroscopy, thin-layer cytology, HPV testing, colposcopy, biopsy when indicated, and/or endocervical curettage. Evaluable data for analysis were collected for 102 of the subjects. Sensitivity and specificity were calculated for both strategies. RESULTS. Pap + HPV and Pap + CS achieved equivalent sensitivities (95%) for high-grade lesions, with both detecting 17 of 18 histology confirmed cervical intraepithelial neoplasia (CIN) 2+ lesions. Pap + HPV had a specificity of only 27.4% compared with 65.5% for Pap + CS (p < .0001). CONCLUSIONS. Spectroscopic interrogation of the cervix is equally sensitive and 2-fold more specific than HPV testing when combined with cervical cytology for identifying high-grade cervical neoplasia.

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