Comparison of intradermal dilutional testing, skin prick testing, and modified quantitative testing for common allergens

Jacques Peltier; Matthew W. Ryan

doi:10.1016/j.otohns.2007.05.002

Comparison of intradermal dilutional testing, skin prick testing, and modified quantitative testing for common allergens

Jacques Peltier, Matthew W. Ryan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objectives: To compare and correlate wheal size using the Multi-Test II applicator with the endpoint obtained by intradermal dilutional testing (IDT) for 5 common allergens. To examine the safety of modified quantitative testing (MQT) for determining immunotherapy starting doses. Study Design: Prospective comparative clinical study. Subjects and Methods: A total of 134 subjects were simultaneously skin tested for immediate hypersensitivity using the Multi-Test II device and IDT. Results: There was a 77% concordance between results from IDT and results from MQT. When there was a difference, MQT predicted a safer endpoint for starting immunotherapy in all but 2 cases. Conclusion: Wheal size by SPT is predictive of endpoint by IDT. MQT is nearly as effective as formal IDT in determining endpoint. Significance: Modified quantitative testing appears to be a safe alternative to IDT for determining starting doses for immunotherapy.

Original language	English (US)
Pages (from-to)	246-249
Number of pages	4
Journal	Otolaryngology - Head and Neck Surgery
Volume	137
Issue number	2
DOIs	https://doi.org/10.1016/j.otohns.2007.05.002
State	Published - Aug 2007

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1016/j.otohns.2007.05.002

Cite this

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title = "Comparison of intradermal dilutional testing, skin prick testing, and modified quantitative testing for common allergens",

abstract = "Objectives: To compare and correlate wheal size using the Multi-Test II applicator with the endpoint obtained by intradermal dilutional testing (IDT) for 5 common allergens. To examine the safety of modified quantitative testing (MQT) for determining immunotherapy starting doses. Study Design: Prospective comparative clinical study. Subjects and Methods: A total of 134 subjects were simultaneously skin tested for immediate hypersensitivity using the Multi-Test II device and IDT. Results: There was a 77% concordance between results from IDT and results from MQT. When there was a difference, MQT predicted a safer endpoint for starting immunotherapy in all but 2 cases. Conclusion: Wheal size by SPT is predictive of endpoint by IDT. MQT is nearly as effective as formal IDT in determining endpoint. Significance: Modified quantitative testing appears to be a safe alternative to IDT for determining starting doses for immunotherapy.",

author = "Jacques Peltier and Ryan, {Matthew W.}",

note = "Funding Information: This study was funded by a grant from the American Academy of Otolaryngic Allergy. ",

year = "2007",

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doi = "10.1016/j.otohns.2007.05.002",

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pages = "246--249",

journal = "Otolaryngology - Head and Neck Surgery",

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T1 - Comparison of intradermal dilutional testing, skin prick testing, and modified quantitative testing for common allergens

AU - Peltier, Jacques

AU - Ryan, Matthew W.

N1 - Funding Information: This study was funded by a grant from the American Academy of Otolaryngic Allergy.

PY - 2007/8

Y1 - 2007/8

N2 - Objectives: To compare and correlate wheal size using the Multi-Test II applicator with the endpoint obtained by intradermal dilutional testing (IDT) for 5 common allergens. To examine the safety of modified quantitative testing (MQT) for determining immunotherapy starting doses. Study Design: Prospective comparative clinical study. Subjects and Methods: A total of 134 subjects were simultaneously skin tested for immediate hypersensitivity using the Multi-Test II device and IDT. Results: There was a 77% concordance between results from IDT and results from MQT. When there was a difference, MQT predicted a safer endpoint for starting immunotherapy in all but 2 cases. Conclusion: Wheal size by SPT is predictive of endpoint by IDT. MQT is nearly as effective as formal IDT in determining endpoint. Significance: Modified quantitative testing appears to be a safe alternative to IDT for determining starting doses for immunotherapy.

AB - Objectives: To compare and correlate wheal size using the Multi-Test II applicator with the endpoint obtained by intradermal dilutional testing (IDT) for 5 common allergens. To examine the safety of modified quantitative testing (MQT) for determining immunotherapy starting doses. Study Design: Prospective comparative clinical study. Subjects and Methods: A total of 134 subjects were simultaneously skin tested for immediate hypersensitivity using the Multi-Test II device and IDT. Results: There was a 77% concordance between results from IDT and results from MQT. When there was a difference, MQT predicted a safer endpoint for starting immunotherapy in all but 2 cases. Conclusion: Wheal size by SPT is predictive of endpoint by IDT. MQT is nearly as effective as formal IDT in determining endpoint. Significance: Modified quantitative testing appears to be a safe alternative to IDT for determining starting doses for immunotherapy.

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Comparison of intradermal dilutional testing, skin prick testing, and modified quantitative testing for common allergens

Abstract

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