Comparison of outcomes in adults with pediatric-onset morphea and those with adult-onset morphea: A cross-sectional study from the morphea in adults and children cohort

Daniel Condie, Daniel Grabell, Heidi Jacobe

Research output: Contribution to journalArticle

27 Scopus citations


Objective Few studies have examined outcomes in adults with pediatric-onset morphea. The objective of the present study was to compare clinical outcomes and health-related quality of life (HRQOL) in adults with onset of morphea in childhood to those in patients with adult onset of morphea.

Methods Participants in the study were drawn from the Morphea in Adults and Children cohort and included 68 adults with pediatric-onset morphea and 234 patients with adult-onset morphea. Outcome measures included the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), physical examination findings, and HRQOL questionnaires.

Results Adults with pediatric-onset morphea were younger, had longer disease duration, and were more likely to have the linear subtype of morphea. Patients with pediatric-onset disease were less likely to have active disease. Among patients with active disease, those with pediatric-onset morphea had less disease activity as measured by the LoSCAT. Patients with pediatric-onset disease had higher severity of disease damage when measured by the physician's global assessment of damage, but had similar levels of disease damage when measured by the Localized Scleroderma Skin Damage Index. Patients with pediatric-onset disease had more favorable HRQOL scores for all measures, all of which were statistically significantly different from those in patients with adult-onset morphea.

Conclusion Adults with pediatric-onset morphea differ from patients with adult-onset disease with respect to disease subtype, severity of disease activity and damage, and levels of HRQOL.

Original languageEnglish (US)
Pages (from-to)3496-3504
Number of pages9
JournalArthritis and Rheumatology
Issue number12
StatePublished - Dec 1 2014


ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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