Comparison of prostate cancer detection at 3-T MRI with and without an endorectal coil: A prospective, paired-patient study

Daniel N Costa, Qing Yuan, Yin Xi, Neil M Rofsky, Robert E Lenkinski, Yair Lotan, Claus Roehrborn, Franto Francis, Debbie Travalini, Ivan Pedrosa

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objectives: To compare the sensitivity of 2 different non-endorectal coil strategies vs. endorectal coil (ERC) magnetic resonance imaging (MRI) for detection of prostate cancer (PCa). Methods: In this prospective, single-center, paired-patient, paired-reader study, 49 men with a clinical indication for MRI underwent non-ERC (phased-array coil only) T2-weighted imaging and diffusion-weighted imaging followed by the same sequences using both ERC and phased-array coils (ERC Protocol). Patients were randomized into 1 of 2 arms: standard non-ERC protocol and augmented non-ERC protocol. Lesions with Likert score≥3 were defined as suspicious for cancer. Radical prostatectomy specimen or combined systematic plus targeted biopsies served as the standard of reference. Cancers were stratified into risk groups according to the National Comprehensive Cancer Network guidelines. Generalized estimating equations with Bonferroni correction were used for comparisons. The level of reader confidence was inferred by the Likert scores assigned to index lesions. Results: The ERC protocol provided sensitivity (78%) superior to MRI without ERC for PCa detection, both with a standard (43%) (P

Original languageEnglish (US)
JournalUrologic Oncology: Seminars and Original Investigations
DOIs
StateAccepted/In press - Dec 29 2015

Keywords

  • Detection
  • Endorectal coil
  • Imaging
  • MRI
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

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