Comparison of quality of life measures in a depressed population

Stephen R. Wisniewski, A. John Rush, Charlene Bryan, Richard Shelton, Madhukar H. Trivedi, Sheila Marcus, Mustafa M. Husain, Steven D. Hollon, Maurizio Fava

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Measures of quality of life have been increasingly used in clinical trials. When designing a study, researchers must decide which quality of life measure to use. Some literature provides guidance through general recommendations, though lacks quantitative comparisons. In this report, 2 general quality of life measures, the 12-Item Short Form Health Survey (SF-12) and the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), are compared in a depressed population. STAR*D data were used to analyze the associations among the SF-12 and the Q-LES-Q. Each measure covers 6 domains, overlapping on 5 (health, self-esteem/well-being, community/productivity, social/love relationships, leisure/creativity), with the SF-12 addressing family and the Q-LES-Q addressing living situations. Strong item-by-item associations exist only between the Q-LES-Q and the SF-12 physical health items. The 2 measures overlap on the domains covered while the lack of correlation between the 2 measures may be attributed to the perspective of each question as the Q-LES-Q measures satisfaction while the SF-12 measures the patient's perception of function.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalJournal of Nervous and Mental Disease
Volume195
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Depression
  • Function
  • Quality of life
  • Satisfaction

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Wisniewski, S. R., Rush, A. J., Bryan, C., Shelton, R., Trivedi, M. H., Marcus, S., Husain, M. M., Hollon, S. D., & Fava, M. (2007). Comparison of quality of life measures in a depressed population. Journal of Nervous and Mental Disease, 195(3), 219-225. https://doi.org/10.1097/01.nmd.0000258229.38212.6f