Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection

Swetha G. Pinninti, Shannon A. Ross, Masako Shimamura, Zdenek Novak, April L. Palmer, Amina Ahmed, Robert W. Tolan, David I. Bernstein, Marian G. Michaels, Pablo J. Sánchez, Karen B. Fowler, Suresh B. Boppana

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

As part of the CMV and Hearing Multicenter Screening (CHIMES) study, 72,239 newborns were screened for cytomegalovirus by rapid culture and real-time PCR of saliva samples. Of the 266 infants with congenital cytomegalovirus infection, discordance between rapid culture and PCR was observed in 14 children, and 13 were identified only by PCR, demonstrating the superiority of the PCR assay.

Original languageEnglish (US)
Pages (from-to)536-537
Number of pages2
JournalPediatric Infectious Disease Journal
Volume34
Issue number5
DOIs
StatePublished - May 21 2015

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Keywords

  • congenital CMV
  • hearing loss
  • late-onset
  • saliva

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Pinninti, S. G., Ross, S. A., Shimamura, M., Novak, Z., Palmer, A. L., Ahmed, A., Tolan, R. W., Bernstein, D. I., Michaels, M. G., Sánchez, P. J., Fowler, K. B., & Boppana, S. B. (2015). Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection. Pediatric Infectious Disease Journal, 34(5), 536-537. https://doi.org/10.1097/INF.0000000000000609