Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection

Swetha G. Pinninti, Shannon A. Ross, Masako Shimamura, Zdenek Novak, April L. Palmer, Amina Ahmed, Robert W. Tolan, David I. Bernstein, Marian G. Michaels, Pablo J. Sánchez, Karen B. Fowler, Suresh B. Boppana

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

As part of the CMV and Hearing Multicenter Screening (CHIMES) study, 72,239 newborns were screened for cytomegalovirus by rapid culture and real-time PCR of saliva samples. Of the 266 infants with congenital cytomegalovirus infection, discordance between rapid culture and PCR was observed in 14 children, and 13 were identified only by PCR, demonstrating the superiority of the PCR assay.

Original languageEnglish (US)
Pages (from-to)536-537
Number of pages2
JournalPediatric Infectious Disease Journal
Volume34
Issue number5
DOIs
StatePublished - May 21 2015

Fingerprint

Cytomegalovirus Infections
Saliva
Polymerase Chain Reaction
Cytomegalovirus
Hearing
Multicenter Studies
Real-Time Polymerase Chain Reaction
Newborn Infant

Keywords

  • congenital CMV
  • hearing loss
  • late-onset
  • saliva

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Pinninti, S. G., Ross, S. A., Shimamura, M., Novak, Z., Palmer, A. L., Ahmed, A., ... Boppana, S. B. (2015). Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection. Pediatric Infectious Disease Journal, 34(5), 536-537. https://doi.org/10.1097/INF.0000000000000609

Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection. / Pinninti, Swetha G.; Ross, Shannon A.; Shimamura, Masako; Novak, Zdenek; Palmer, April L.; Ahmed, Amina; Tolan, Robert W.; Bernstein, David I.; Michaels, Marian G.; Sánchez, Pablo J.; Fowler, Karen B.; Boppana, Suresh B.

In: Pediatric Infectious Disease Journal, Vol. 34, No. 5, 21.05.2015, p. 536-537.

Research output: Contribution to journalArticle

Pinninti, SG, Ross, SA, Shimamura, M, Novak, Z, Palmer, AL, Ahmed, A, Tolan, RW, Bernstein, DI, Michaels, MG, Sánchez, PJ, Fowler, KB & Boppana, SB 2015, 'Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection', Pediatric Infectious Disease Journal, vol. 34, no. 5, pp. 536-537. https://doi.org/10.1097/INF.0000000000000609
Pinninti, Swetha G. ; Ross, Shannon A. ; Shimamura, Masako ; Novak, Zdenek ; Palmer, April L. ; Ahmed, Amina ; Tolan, Robert W. ; Bernstein, David I. ; Michaels, Marian G. ; Sánchez, Pablo J. ; Fowler, Karen B. ; Boppana, Suresh B. / Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection. In: Pediatric Infectious Disease Journal. 2015 ; Vol. 34, No. 5. pp. 536-537.
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