Comparison of salivary calmodulin binding proteins in Sjögren's syndrome and healthy individuals

Fanasy P. Deming, Ibtisam Al-Hashimi, Nasser Haghighat, William W. Hallmon, David G. Kerns, Celeste Abraham, Francisco Rivera-Hidalgo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Reduction in salivary secretion is the hallmark of Sjögren's syndrome (SS). Calmodulin (CaM) and calmodulin binding proteins (CaMBPs) play a key role in the secretory process of saliva. Recent studies have suggested that SS-B, an autoantibody associated with SS, is a CaMBP. This finding suggests that CaMBP may contribute to the loss of saliva in SS. To better understand the role(s) of these proteins in SS, the purpose of this study was to compare salivary CaMBPs in Sjögren's patients and controls. Methods: Saliva samples were collected from 20 patients and 20 age-, race-, and gender-matched controls. CaM overlay was used to identify CaMBPs in saliva of patients and controls. Results: Higher number of salivary CaMBPs was observed among patients than controls. Conclusions: The increased number of salivary CaMBPs in SS may suggest a potential role for these proteins in the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalJournal of Oral Pathology and Medicine
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2007

Fingerprint

Salivary Proteins and Peptides
Calmodulin-Binding Proteins
Saliva
Calmodulin
Secretory Pathway
Autoantibodies
Proteins

Keywords

  • Calmodulin binding proteins
  • Dry mouth
  • Pathogenesis
  • Saliva
  • Salivary gland dysfunction
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Comparison of salivary calmodulin binding proteins in Sjögren's syndrome and healthy individuals. / Deming, Fanasy P.; Al-Hashimi, Ibtisam; Haghighat, Nasser; Hallmon, William W.; Kerns, David G.; Abraham, Celeste; Rivera-Hidalgo, Francisco.

In: Journal of Oral Pathology and Medicine, Vol. 36, No. 3, 01.03.2007, p. 132-135.

Research output: Contribution to journalArticle

Deming, Fanasy P. ; Al-Hashimi, Ibtisam ; Haghighat, Nasser ; Hallmon, William W. ; Kerns, David G. ; Abraham, Celeste ; Rivera-Hidalgo, Francisco. / Comparison of salivary calmodulin binding proteins in Sjögren's syndrome and healthy individuals. In: Journal of Oral Pathology and Medicine. 2007 ; Vol. 36, No. 3. pp. 132-135.
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