Abstract
Cefaclor and rifampin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an expla nation of the efficacy of rifampin and the inability of cefacior to eradicate pharyngeal carriage of Hemophilus strains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 397-399 |
| Number of pages | 3 |
| Journal | Clinical Pediatrics |
| Volume | 21 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1982 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health