Comparison of Salivary Concentrations of Rifampin and Cefaclor: A Rationale for Chemoprophylaxis of Hemophilus influenzae type b Disease

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Abstract

Cefaclor and rifampin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an expla nation of the efficacy of rifampin and the inability of cefacior to eradicate pharyngeal carriage of Hemophilus strains.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalClinical Pediatrics
Volume21
Issue number7
DOIs
StatePublished - Jul 1982

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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