Comparison of salivary concentrations of rifampin and cefaclor. A rationale for chemoprophylaxis of hemophilus influenzae type b disease

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Abstract

Cefaclor and rifampicin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an explanation of the efficacy of rifampicin and the inability of cefaclor to eradicate pharyngeal carriage of Hemophilus strains.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalClinical Pediatrics
Volume21
Issue number7
StatePublished - 1982

Fingerprint

Cefaclor
Haemophilus influenzae type b
Chemoprevention
Rifampin
Eating
Saliva
Capsules
Pharmaceutical Preparations
Haemophilus
Suspensions
Healthy Volunteers
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Comparison of salivary concentrations of rifampin and cefaclor. A rationale for chemoprophylaxis of hemophilus influenzae type b disease",
abstract = "Cefaclor and rifampicin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an explanation of the efficacy of rifampicin and the inability of cefaclor to eradicate pharyngeal carriage of Hemophilus strains.",
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year = "1982",
language = "English (US)",
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journal = "Clinical Pediatrics",
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N2 - Cefaclor and rifampicin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an explanation of the efficacy of rifampicin and the inability of cefaclor to eradicate pharyngeal carriage of Hemophilus strains.

AB - Cefaclor and rifampicin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an explanation of the efficacy of rifampicin and the inability of cefaclor to eradicate pharyngeal carriage of Hemophilus strains.

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