Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers. Clinical and confocal microscopy findings

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Abstract

Purpose: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). Setting: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Methods: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. Results: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 μm ± 11.1 (SD) and 13.9 ± 7.1 μm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 ± 88.6 confocal backscatter units (CBU) and 104.8 ± 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 ± 14.8 particles/mm2 in the FS15 group and 11.0 ± 7.1 particles/mm2 in the FS30 group (P<.05). Conclusions: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.

Original languageEnglish (US)
Pages (from-to)673-681
Number of pages9
JournalJournal of Cataract and Refractive Surgery
Volume33
Issue number4
DOIs
StatePublished - Apr 2007

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Laser In Situ Keratomileusis
Confocal Microscopy
Lasers
Corneal Keratocytes
Ophthalmology
Cornea

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{16e3a4c69a1044b89815c3f9108f493b,
title = "Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers. Clinical and confocal microscopy findings",
abstract = "Purpose: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). Setting: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Methods: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. Results: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 μm ± 11.1 (SD) and 13.9 ± 7.1 μm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 ± 88.6 confocal backscatter units (CBU) and 104.8 ± 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 ± 14.8 particles/mm2 in the FS15 group and 11.0 ± 7.1 particles/mm2 in the FS30 group (P<.05). Conclusions: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.",
author = "Hu, {Michael Y.} and McCulley, {James P} and Cavanagh, {Harrison D} and Bowman, {Robert W} and Steven Verity and Venkateswara Mootha and Petroll, {Walter M}",
year = "2007",
month = "4",
doi = "10.1016/j.jcrs.2006.12.021",
language = "English (US)",
volume = "33",
pages = "673--681",
journal = "Journal of Cataract and Refractive Surgery",
issn = "0886-3350",
publisher = "Elsevier Inc.",
number = "4",

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TY - JOUR

T1 - Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers. Clinical and confocal microscopy findings

AU - Hu, Michael Y.

AU - McCulley, James P

AU - Cavanagh, Harrison D

AU - Bowman, Robert W

AU - Verity, Steven

AU - Mootha, Venkateswara

AU - Petroll, Walter M

PY - 2007/4

Y1 - 2007/4

N2 - Purpose: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). Setting: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Methods: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. Results: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 μm ± 11.1 (SD) and 13.9 ± 7.1 μm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 ± 88.6 confocal backscatter units (CBU) and 104.8 ± 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 ± 14.8 particles/mm2 in the FS15 group and 11.0 ± 7.1 particles/mm2 in the FS30 group (P<.05). Conclusions: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.

AB - Purpose: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). Setting: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Methods: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. Results: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 μm ± 11.1 (SD) and 13.9 ± 7.1 μm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 ± 88.6 confocal backscatter units (CBU) and 104.8 ± 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 ± 14.8 particles/mm2 in the FS15 group and 11.0 ± 7.1 particles/mm2 in the FS30 group (P<.05). Conclusions: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.

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U2 - 10.1016/j.jcrs.2006.12.021

DO - 10.1016/j.jcrs.2006.12.021

M3 - Article

VL - 33

SP - 673

EP - 681

JO - Journal of Cataract and Refractive Surgery

JF - Journal of Cataract and Refractive Surgery

SN - 0886-3350

IS - 4

ER -