Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat

Massimo Carrella, John M. Dietschy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To compare the ability of cholic acid and chenic acid to suppress cholesterol synthesis in the liver, these two bile acids were fed in varying amounts to rats for either 66 hr or 6 weeks. In both instances there were significant changes in the bile acid pool in the small intestine and suppression of the rate of cholesterol synthesis in the liver. The administration of cholic acid, however, consistently produced greater suppression of the rate of cholesterol synthesis from octanoate or of microsomal HMG CoA reductase activity than did the administration of a similar amount of chenic acid. Furthermore, this difference was present whether the rates of cholesterogenesis were measured at high-substrate concentrations, ie, under conditions where Vmax was apparently achieved, or under circumstances where there was essentially no extracellular substrate present. These findings do not support the view that the superiority of chenic acid for dissolution of gallstones is secondary to its greater effect as an inhibitor of hepatic cholesterol synthesis.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalThe American Journal of Digestive Diseases
Volume22
Issue number4
DOIs
StatePublished - Apr 1977

Fingerprint

Chenodeoxycholic Acid
Cholic Acid
Cholesterol
Bile Acids and Salts
Liver
Anticholesteremic Agents
Hydroxymethylglutaryl CoA Reductases
Gallstones
Small Intestine

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat. / Carrella, Massimo; Dietschy, John M.

In: The American Journal of Digestive Diseases, Vol. 22, No. 4, 04.1977, p. 318-326.

Research output: Contribution to journalArticle

@article{b4fa9c77def5475cb6d855edea2a7587,
title = "Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat",
abstract = "To compare the ability of cholic acid and chenic acid to suppress cholesterol synthesis in the liver, these two bile acids were fed in varying amounts to rats for either 66 hr or 6 weeks. In both instances there were significant changes in the bile acid pool in the small intestine and suppression of the rate of cholesterol synthesis in the liver. The administration of cholic acid, however, consistently produced greater suppression of the rate of cholesterol synthesis from octanoate or of microsomal HMG CoA reductase activity than did the administration of a similar amount of chenic acid. Furthermore, this difference was present whether the rates of cholesterogenesis were measured at high-substrate concentrations, ie, under conditions where Vmax was apparently achieved, or under circumstances where there was essentially no extracellular substrate present. These findings do not support the view that the superiority of chenic acid for dissolution of gallstones is secondary to its greater effect as an inhibitor of hepatic cholesterol synthesis.",
author = "Massimo Carrella and Dietschy, {John M.}",
year = "1977",
month = "4",
doi = "10.1007/BF01072189",
language = "English (US)",
volume = "22",
pages = "318--326",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Comparison of the effects of cholic acid and chenic acid feeding on rates of cholesterol synthesis in the liver of the rat

AU - Carrella, Massimo

AU - Dietschy, John M.

PY - 1977/4

Y1 - 1977/4

N2 - To compare the ability of cholic acid and chenic acid to suppress cholesterol synthesis in the liver, these two bile acids were fed in varying amounts to rats for either 66 hr or 6 weeks. In both instances there were significant changes in the bile acid pool in the small intestine and suppression of the rate of cholesterol synthesis in the liver. The administration of cholic acid, however, consistently produced greater suppression of the rate of cholesterol synthesis from octanoate or of microsomal HMG CoA reductase activity than did the administration of a similar amount of chenic acid. Furthermore, this difference was present whether the rates of cholesterogenesis were measured at high-substrate concentrations, ie, under conditions where Vmax was apparently achieved, or under circumstances where there was essentially no extracellular substrate present. These findings do not support the view that the superiority of chenic acid for dissolution of gallstones is secondary to its greater effect as an inhibitor of hepatic cholesterol synthesis.

AB - To compare the ability of cholic acid and chenic acid to suppress cholesterol synthesis in the liver, these two bile acids were fed in varying amounts to rats for either 66 hr or 6 weeks. In both instances there were significant changes in the bile acid pool in the small intestine and suppression of the rate of cholesterol synthesis in the liver. The administration of cholic acid, however, consistently produced greater suppression of the rate of cholesterol synthesis from octanoate or of microsomal HMG CoA reductase activity than did the administration of a similar amount of chenic acid. Furthermore, this difference was present whether the rates of cholesterogenesis were measured at high-substrate concentrations, ie, under conditions where Vmax was apparently achieved, or under circumstances where there was essentially no extracellular substrate present. These findings do not support the view that the superiority of chenic acid for dissolution of gallstones is secondary to its greater effect as an inhibitor of hepatic cholesterol synthesis.

UR - http://www.scopus.com/inward/record.url?scp=0017336204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017336204&partnerID=8YFLogxK

U2 - 10.1007/BF01072189

DO - 10.1007/BF01072189

M3 - Article

C2 - 857658

AN - SCOPUS:0017336204

VL - 22

SP - 318

EP - 326

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 4

ER -