Comparison of three neurotropic viruses reveals differences in viral dissemination to the centrl nervous system

Lauren N. Luethy, Andrea K. Erickson, Palmy R. Jesudhasan, Mine Ikizler, Terence S. Dermody, Julie K. Pfeiffer

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Neurotropic viruses initiate infection in peripheral tissues prior to entry into the central nervous system (CNS). However, mechanisms of dissemination are not completely understood. We used genetically marked viruses to compare dissemination of poliovirus, yellow fever virus 17D (YFV-17D), and reovirus type 3 Dearing in mice from a hind limb intramuscular inoculation site to the sciatic nerve, spinal cord, and brain. While YFV-17D likely entered the CNS via blood, poliovirus and reovirus likely entered the CNS by transport through the sciatic nerve to the spinal cord. We found that dissemination was inefficient in adult immune-competent mice for all three viruses, particularly reovirus. Dissemination of all viruses was more efficient in immune-deficient mice. Although poliovirus and reovirus both accessed the CNS by transit through the sciatic nerve, stimulation of neuronal transport by muscle damage enhanced dissemination only of poliovirus. Our results suggest that these viruses access the CNS using different pathways.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalVirology
Volume487
DOIs
StatePublished - Jan 1 2016

Keywords

  • Barrier
  • Interferon
  • Neurotropic
  • Poliovirus
  • Reovirus
  • Sciatic nerve
  • Virus
  • Yellow fever virus 17D

ASJC Scopus subject areas

  • Virology

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