Comparison of trimethoprim-sulfamethoxazole and ampicillin therapy for shigellosis in ambulatory patients

John D. Nelson, Helen Kusmiesz, Lula Hinton Jackson

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

One hundred seventy-four infants and children with acute diarrhea were treated as ambulatory patients with either ampicillin (100 mg/kg/day orally in four divided doses) or trimethoprim sulfamethoxazole (10 mg TMP and 50 mg SMX/kg/day orally in two divided doses). There were 65 patients with shigellosis. Responses of those treated with TMP/SMX and of those with susceptible Shigella treated with ampicillin were comparable. Patients with resistant organisms failed to respond to ampicillin. All Shigella, including ampicillin-resistant strains, were susceptible in vitro to TMP/SMX, and patients with ampicillin-resistant strains responded favorably to treatment with TMP/SMX. TMP/SMX appears to be the best, currently available drug for the treatment of shigellosis.

Original languageEnglish (US)
Pages (from-to)491-493
Number of pages3
JournalThe Journal of pediatrics
Volume89
Issue number3
DOIs
StatePublished - Sep 1976

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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