Comparison of1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation

Dawen Zhao, Lan Jiang, Eric W. Hahn, Ralph P. Mason

Research output: Contribution to journalArticle

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Abstract

Fluorine-19 [19F] MRI oximetry and 1H blood oxygen level-dependent (BOLD) MRI were used to investigate tumor oxygenation in rat breast 13762NF carcinomas, and correlations between the techniques were examined. A range of tissue oxygen partial pressure (pO2) values was found in the nine tumors while the anesthetized rats breathed air, with individual tumor pO2 ranging from a mean of 1 to 36 torr and hypoxic fraction (HF10) (<10 torr) ranging from 0% to 75%, indicating a large intra- and intertumor heterogeneity. Breathing oxygen produced significant increase in tumor pO2 (mean ΔpO2 = 50 torr) and decrease in HF10 (P < 0.01). 1H BOLD MRI observed using a spin echoplanar imaging (EPI) sequence revealed a heterogeneous response and significant increase in mean tumor signal intensity (SI) (ΔSI = 7%, P < 0.01). R2* measured by multigradient-echo (MGRE) MRI decreased significantly in response to oxygen (mean ΔR2* = -4 s-1; P < 0.05). A significant correlation was found between changes in mean tumor pO2 and mean EPI BOLD ΔSI accompanying oxygen breathing (r2 > 0.7, P < 0.001). Our results suggest that BOLD MRI provides information about tumor oxygenation and may be useful to predict pO2 changes accompanying interventions. Significantly, the magnitude of the BOLD response appears to be predictive for residual tumor HFs.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalMagnetic Resonance in Medicine
Volume62
Issue number2
DOIs
StatePublished - Aug 2009

Fingerprint

Oxygen
Neoplasms
Oximetry
Fluorine
Partial Pressure
Residual Neoplasm
Air
Breast Neoplasms
Fluorine-19 Magnetic Resonance Imaging

Keywords

  • F MRI
  • BOLD
  • Hexafluorobenzene
  • Oxygen
  • Transverse relaxation rate R *
  • Tumor oxygenation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Comparison of1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation. / Zhao, Dawen; Jiang, Lan; Hahn, Eric W.; Mason, Ralph P.

In: Magnetic Resonance in Medicine, Vol. 62, No. 2, 08.2009, p. 357-364.

Research output: Contribution to journalArticle

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abstract = "Fluorine-19 [19F] MRI oximetry and 1H blood oxygen level-dependent (BOLD) MRI were used to investigate tumor oxygenation in rat breast 13762NF carcinomas, and correlations between the techniques were examined. A range of tissue oxygen partial pressure (pO2) values was found in the nine tumors while the anesthetized rats breathed air, with individual tumor pO2 ranging from a mean of 1 to 36 torr and hypoxic fraction (HF10) (<10 torr) ranging from 0{\%} to 75{\%}, indicating a large intra- and intertumor heterogeneity. Breathing oxygen produced significant increase in tumor pO2 (mean ΔpO2 = 50 torr) and decrease in HF10 (P < 0.01). 1H BOLD MRI observed using a spin echoplanar imaging (EPI) sequence revealed a heterogeneous response and significant increase in mean tumor signal intensity (SI) (ΔSI = 7{\%}, P < 0.01). R2* measured by multigradient-echo (MGRE) MRI decreased significantly in response to oxygen (mean ΔR2* = -4 s-1; P < 0.05). A significant correlation was found between changes in mean tumor pO2 and mean EPI BOLD ΔSI accompanying oxygen breathing (r2 > 0.7, P < 0.001). Our results suggest that BOLD MRI provides information about tumor oxygenation and may be useful to predict pO2 changes accompanying interventions. Significantly, the magnitude of the BOLD response appears to be predictive for residual tumor HFs.",
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