TY - JOUR
T1 - Comparisons of metabolism of apolipoprotein B in normal subjects, obese patients, and patients with coronary heart disease
AU - Kesaniemi, Y. A.
AU - Beltz, W. F.
AU - Grundy, Scott M
PY - 1985
Y1 - 1985
N2 - This study was designed to examine the integrated metabolism of apolipoprotein B (apo B) in very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and low density lipoproteins (LDL) in normal subjects, obese patients, and a group of patients with coronary heart disease (CHD). Turnover rates of 131I-VLDL-B, 131I-IDL-B, 125I-LDL-B, and [3H]VLDL-triglycerides (TG) were determined by the multicompartmental analysis that used the model described in the preceding article (Beltz, W.F., et al. 1985. J. Clin. Invest. 76: 575-585). Compared with five normal subjects, four obese subjects had increased synthesis rates of both VLDL-B and VLDL-TG. Production of LDL-B was inconsistently raised in these same patients. Five patients with CHD had enhanced production of both VLDL-B and LDL-B, but secretion rates of VLDL-TG were not increased. Thus, in patients with obesity and in those with CHD, synthesis rates of VLDL particles may be abnormally high. In the obese patients, the VLDL appeared to be of normal composition, but in patients with CHD, and VLDL were relatively poor in TG. The study also showed that a significant fraction of VLDL-B is removed directly from the circulation and never reaches LDL regardless of the type of patients. The fraction that does reach LDL is one factor that determines LDL concentrations.
AB - This study was designed to examine the integrated metabolism of apolipoprotein B (apo B) in very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and low density lipoproteins (LDL) in normal subjects, obese patients, and a group of patients with coronary heart disease (CHD). Turnover rates of 131I-VLDL-B, 131I-IDL-B, 125I-LDL-B, and [3H]VLDL-triglycerides (TG) were determined by the multicompartmental analysis that used the model described in the preceding article (Beltz, W.F., et al. 1985. J. Clin. Invest. 76: 575-585). Compared with five normal subjects, four obese subjects had increased synthesis rates of both VLDL-B and VLDL-TG. Production of LDL-B was inconsistently raised in these same patients. Five patients with CHD had enhanced production of both VLDL-B and LDL-B, but secretion rates of VLDL-TG were not increased. Thus, in patients with obesity and in those with CHD, synthesis rates of VLDL particles may be abnormally high. In the obese patients, the VLDL appeared to be of normal composition, but in patients with CHD, and VLDL were relatively poor in TG. The study also showed that a significant fraction of VLDL-B is removed directly from the circulation and never reaches LDL regardless of the type of patients. The fraction that does reach LDL is one factor that determines LDL concentrations.
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U2 - 10.1172/JCI112010
DO - 10.1172/JCI112010
M3 - Article
C2 - 3861622
AN - SCOPUS:0021960801
SN - 0021-9738
VL - 76
SP - 586
EP - 595
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 2
ER -