Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae

Qing Qing Fan, Fei Xu, Michael A. White, Thomas D. Petes

Research output: Contribution to journalArticle

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Abstract

In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.

Original languageEnglish (US)
Pages (from-to)661-670
Number of pages10
JournalGenetics
Volume145
Issue number3
Publication statusPublished - Mar 1997

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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