Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses

Karen M. Haas, Minoru Hasegawa, Douglas A. Steeber, Jonathan C. Poe, Mark D. Zabel, Cheryl B. Bock, David R. Karp, David E. Briles, John H. Weis, Thomas F. Tedder

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

The CD21/35 receptor provides an important link between innate and adaptive immunity. Its importance during protective immune responses to encapsulated extracellular bacteria was assessed using a new line of mice completely deficient in CD21/35 expression (CD21/35-/-). CD21/35 expression was essential for the rapid trapping of C3dg-antigen complexes by B cells in vivo, especially in splenic marginal zones. Despite normal B cell development in CD21/35-/- mice, T cell-independent and -dependent antibody responses to low-dose antigens were significantly decreased, with a striking impairment in IgG3 responses. Accordingly, CD21/35-/- mice were more susceptible to acute lethal Streptococcus pneumoniae infection. Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system.

Original languageEnglish (US)
Pages (from-to)713-723
Number of pages11
JournalImmunity
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2002

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Pneumococcal Infections
Complement Receptors
Innate Immunity
Antibody Formation
Immunoglobulin G
B-Lymphocytes
Antigens
Adaptive Immunity
Immune System
Bacteria
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. / Haas, Karen M.; Hasegawa, Minoru; Steeber, Douglas A.; Poe, Jonathan C.; Zabel, Mark D.; Bock, Cheryl B.; Karp, David R.; Briles, David E.; Weis, John H.; Tedder, Thomas F.

In: Immunity, Vol. 17, No. 6, 01.12.2002, p. 713-723.

Research output: Contribution to journalArticle

Haas, KM, Hasegawa, M, Steeber, DA, Poe, JC, Zabel, MD, Bock, CB, Karp, DR, Briles, DE, Weis, JH & Tedder, TF 2002, 'Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses', Immunity, vol. 17, no. 6, pp. 713-723. https://doi.org/10.1016/S1074-7613(02)00483-1
Haas, Karen M. ; Hasegawa, Minoru ; Steeber, Douglas A. ; Poe, Jonathan C. ; Zabel, Mark D. ; Bock, Cheryl B. ; Karp, David R. ; Briles, David E. ; Weis, John H. ; Tedder, Thomas F. / Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. In: Immunity. 2002 ; Vol. 17, No. 6. pp. 713-723.
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