Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation

Wen Hao Zhang, He Wang, Aihua Chen, Yong Gu, Tai Sing Lee, Ky Michael Wong, Si Wu

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Our brain perceives the world by exploiting multisensory cues to extract information about various aspects of external stimuli. The sensory cues from the same stimulus should be integrated to improve perception, and otherwise segregated to distinguish different stimuli. In reality, however, the brain faces the challenge of recognizing stimuli without knowing in advance the sources of sensory cues. To address this challenge, we propose that the brain conducts integration and segregation concurrently with complementary neurons. Studying the inference of heading-direction via visual and vestibular cues, we develop a network model with two reciprocally connected modules modeling interacting visual-vestibular areas. In each module, there are two groups of neurons whose tunings under each sensory cue are either congruent or opposite. We show that congruent neurons implement integration, while opposite neurons compute cue disparity information for segregation, and the interplay between two groups of neurons achieves efficient multisensory information processing.

Original languageEnglish (US)
Article numbere43753
JournaleLife
Volume8
DOIs
StatePublished - May 2019
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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