Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease

James S. Tweddell, Andrew N. Pelech, Peter C. Frommelt, Robert D.B. Jaquiss, George M. Hoffman, Kathleen A. Mussatto, S. Bert Litwin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: This study was undertaken to determine the utility of aortic valve repair in children. Methods: A retrospective analysis was conducted on aortic valve surgery from 1973 to 2004 at Children's Hospital of Wisconsin. Results: Procedures were classified as simple repairs (blunt valvotomy, commissurotomy with or without thinning, n = 147), repair of aortic insufficiency with ventricular septal defect (n = 22), complex repairs (any combination of additional procedures including suspension of prolapsed leaflets, leaflet extensions, repair of torn or perforated leaflets, annuloplasty, reduction of sinus of Valsalva plasty, and concomitant repair of supravalvular or subvalvular stenosis, n = 57), and replacements (n = 57, 20 mechanical, 2 porcine, and 35 human valves). Freedoms from reintervention for simple repairs and repair of aortic insufficiency with ventricular septal defect at 10 years were 86% ± 5% and 93.3% ± 6%, respectively. For complex valve repair, freedoms from reintervention at 1, 5, and 10 years were 94% ± 3%, 85% ± 6%, and 44% ± 15%, versus 96% ± 3%, 77% ± 9%, and 77% ± 9% for valve replacement (P =. 3). At intermediate follow-up, patients with complex valve repair had a residual gradient of 20 ± 21 mm Hg, and 94% were free of severe aortic insufficiency. Residual aortic stenosis (P <. 05) but not the preoperative diagnosis of combined aortic stenosis and insufficiency predicted the need for reintervention. Conclusion: Freedom from reintervention after complex valve repairs was not different from that after valve replacement, with acceptable residual aortic stenosis and insufficiency. Simple repairs and repair of aortic insufficiency with ventricular septal defect yielded excellent long-term freedom from reintervention.

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume129
Issue number3
DOIs
StatePublished - Jan 1 2005

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Aortic Diseases
Aortic Valve
Ventricular Heart Septal Defects
Aortic Valve Stenosis
Sinus of Valsalva
Suspensions
Pathologic Constriction
Swine

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease. / Tweddell, James S.; Pelech, Andrew N.; Frommelt, Peter C.; Jaquiss, Robert D.B.; Hoffman, George M.; Mussatto, Kathleen A.; Litwin, S. Bert.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 129, No. 3, 01.01.2005, p. 551-558.

Research output: Contribution to journalArticle

Tweddell, James S. ; Pelech, Andrew N. ; Frommelt, Peter C. ; Jaquiss, Robert D.B. ; Hoffman, George M. ; Mussatto, Kathleen A. ; Litwin, S. Bert. / Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease. In: Journal of Thoracic and Cardiovascular Surgery. 2005 ; Vol. 129, No. 3. pp. 551-558.
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AB - Objective: This study was undertaken to determine the utility of aortic valve repair in children. Methods: A retrospective analysis was conducted on aortic valve surgery from 1973 to 2004 at Children's Hospital of Wisconsin. Results: Procedures were classified as simple repairs (blunt valvotomy, commissurotomy with or without thinning, n = 147), repair of aortic insufficiency with ventricular septal defect (n = 22), complex repairs (any combination of additional procedures including suspension of prolapsed leaflets, leaflet extensions, repair of torn or perforated leaflets, annuloplasty, reduction of sinus of Valsalva plasty, and concomitant repair of supravalvular or subvalvular stenosis, n = 57), and replacements (n = 57, 20 mechanical, 2 porcine, and 35 human valves). Freedoms from reintervention for simple repairs and repair of aortic insufficiency with ventricular septal defect at 10 years were 86% ± 5% and 93.3% ± 6%, respectively. For complex valve repair, freedoms from reintervention at 1, 5, and 10 years were 94% ± 3%, 85% ± 6%, and 44% ± 15%, versus 96% ± 3%, 77% ± 9%, and 77% ± 9% for valve replacement (P =. 3). At intermediate follow-up, patients with complex valve repair had a residual gradient of 20 ± 21 mm Hg, and 94% were free of severe aortic insufficiency. Residual aortic stenosis (P <. 05) but not the preoperative diagnosis of combined aortic stenosis and insufficiency predicted the need for reintervention. Conclusion: Freedom from reintervention after complex valve repairs was not different from that after valve replacement, with acceptable residual aortic stenosis and insufficiency. Simple repairs and repair of aortic insufficiency with ventricular septal defect yielded excellent long-term freedom from reintervention.

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