Complex aphthosis: A forme fruste of Behcet's syndrome?

J. L. Jorizzo, R. S. Taylor, F. C. Schmalstieg, A. R. Solomon, J. C. Daniels, H. E. Rudloff, T. Cavallo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The evaluation of the rare patient who represents with oral and genital aphthae or almost constant, multiple (>3) oral aphthae, but no systemic signs or symptoms (i.e., complex aphthosis), is difficult because no laboratory test is available to exclude Behcet's syndrome. Six patients with complex aphthosis were evaluated. In addition, patients with simple aphthosis, those with seronegative arthritis, and normal controls were assessed for circulating immune complexes (CIC) by in vitro and in vivo assays and for neutrophil migration by subagarose methods, since these tests have given significant results in patients with Behcet's syndrome. Patient 1, with complex aphthosis, had Raji cell evidence for CIC (51.2 mg aggregated human gamma globulin Eq/ml), and C1q, and C3 in dermal blood vessels 4 hours post intradermal histamine injection and had a Sweet's syndrome-like vasculitis 24 hours post histamine injection. In addition, her serum enhanced the migration of patient neutrophils (3.6 ± 0.6 to 4.6 ± 0.5; N = 6, p ≤ 0.01). All other test and control patients had negative or normal CIC and neutrophil migration determinations. Sixteen-month clinical follow-up has confirmed that Patient 1, but not Patients 2 to 6, has developed overt manifestations of Behcet's syndrome.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume13
Issue number1
DOIs
StatePublished - 1985

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Behcet Syndrome
Antigen-Antibody Complex
Aphthous Stomatitis
Neutrophils
Histamine
Sweet Syndrome
Intradermal Injections
gamma-Globulins
Vasculitis
Signs and Symptoms
Arthritis
Blood Vessels
Skin
Injections

ASJC Scopus subject areas

  • Dermatology

Cite this

Jorizzo, J. L., Taylor, R. S., Schmalstieg, F. C., Solomon, A. R., Daniels, J. C., Rudloff, H. E., & Cavallo, T. (1985). Complex aphthosis: A forme fruste of Behcet's syndrome? Journal of the American Academy of Dermatology, 13(1), 80-84. https://doi.org/10.1016/S0190-9622(85)70147-8

Complex aphthosis : A forme fruste of Behcet's syndrome? / Jorizzo, J. L.; Taylor, R. S.; Schmalstieg, F. C.; Solomon, A. R.; Daniels, J. C.; Rudloff, H. E.; Cavallo, T.

In: Journal of the American Academy of Dermatology, Vol. 13, No. 1, 1985, p. 80-84.

Research output: Contribution to journalArticle

Jorizzo, JL, Taylor, RS, Schmalstieg, FC, Solomon, AR, Daniels, JC, Rudloff, HE & Cavallo, T 1985, 'Complex aphthosis: A forme fruste of Behcet's syndrome?', Journal of the American Academy of Dermatology, vol. 13, no. 1, pp. 80-84. https://doi.org/10.1016/S0190-9622(85)70147-8
Jorizzo JL, Taylor RS, Schmalstieg FC, Solomon AR, Daniels JC, Rudloff HE et al. Complex aphthosis: A forme fruste of Behcet's syndrome? Journal of the American Academy of Dermatology. 1985;13(1):80-84. https://doi.org/10.1016/S0190-9622(85)70147-8
Jorizzo, J. L. ; Taylor, R. S. ; Schmalstieg, F. C. ; Solomon, A. R. ; Daniels, J. C. ; Rudloff, H. E. ; Cavallo, T. / Complex aphthosis : A forme fruste of Behcet's syndrome?. In: Journal of the American Academy of Dermatology. 1985 ; Vol. 13, No. 1. pp. 80-84.
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