Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection

Carolyn R. Sturge, Felix Yarovinsky

Research output: Contribution to journalShort surveypeer-review

54 Scopus citations

Abstract

Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ -producing cells and the signals that regulate IFN-γ production during T. gondii infection.

Original languageEnglish (US)
Pages (from-to)3090-3097
Number of pages8
JournalInfection and immunity
Volume82
Issue number8
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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