Abstract
Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ -producing cells and the signals that regulate IFN-γ production during T. gondii infection.
Original language | English (US) |
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Pages (from-to) | 3090-3097 |
Number of pages | 8 |
Journal | Infection and immunity |
Volume | 82 |
Issue number | 8 |
DOIs | |
State | Published - 2014 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases