Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection

Carolyn R. Sturge, Felix Yarovinsky

Research output: Contribution to journalShort survey

46 Scopus citations

Abstract

Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ -producing cells and the signals that regulate IFN-γ production during T. gondii infection.

Original languageEnglish (US)
Pages (from-to)3090-3097
Number of pages8
JournalInfection and immunity
Volume82
Issue number8
DOIs
StatePublished - 2014

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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