Complex roles of PIP2 in the regulation of ion channels and transporters

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

The regulation of ion channels and transporters by phosphoinositides has received much attention over the past 10 years. There are multiple potential mechanisms for regulation of ion channels and transporters by PIP2, including a direct binding of PIP2 to the target proteins, alterations of membrane insertion, and retrieval. Added to the complexities of multiple potential mechanisms is how cells use PIP2 to regulate so many different processes. Here, I briefly review several past and recent studies to illustrate the complexities and raise outstanding questions for future studies.

Original languageEnglish (US)
Pages (from-to)F1761-F1765
JournalAmerican Journal of Physiology - Renal Physiology
Volume293
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Arf
  • Endocytosis
  • Exocytosis
  • PIP5K
  • Phosphoinositide
  • Rho

ASJC Scopus subject areas

  • Physiology
  • Urology

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