Complex wavefront corrections for deep tissue focusing using low coherence backscattered light

Reto Fiolka, Ke Si, Meng Cui

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Aberrations and random scattering severely limit optical imaging in deep tissue. Adaptive optics can in principle drastically extend the penetration depth and improve the image quality. However, for random scattering media a large number of spatial modes need to be measured and controlled to restore a diffraction limited focus. Here, we present a parallel wavefront optimization method using backscattered light as a feedback. Spatial confinement of the feedback signal is realized with a confocal pinhole and coherence gating. We show in simulations and experiments that this approach enables focusing deep into tissue over up to six mean scattering path lengths. Experimentally the technique was tested on tissue phantoms and fixed brain slices.

Original languageEnglish (US)
Pages (from-to)16532-16543
Number of pages12
JournalOptics Express
Volume20
Issue number15
DOIs
StatePublished - Jul 16 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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