Complications following prostaglandin F2(α) induced midtrimester abortion

J. H. Duenhoelter, N. F. Gant

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Prostaglandin F2(α) [PGF2(α)] was injected intraamniotically in 122 patients between 14 and 20 wk gestation in the dosage schedule recommended by the drug manufacturer to induce abortion. Significantly more multiparous (47.5%) than primigravida patients (21.5%) aborted within 16 hr, but the mean duration between PGF2(α) injection and abortion was not significantly different. Complications occurred in 52 (42.6%) patients and included: fall in hematocrit of more than 5 percentage points, failure to abort within 48 hr after injection, infection requiring antibiotic therapy, cervical laceration or fistula, and uterine rupture. The atypical dilatation and effacement of the cervix occurring with PGF2(α) induced contractions may possibly lead to cervical incompetence with later pregnancies. Although the efficacy of PGF2(α) as an abortifacient is confirmed, the large complication rate with the procedure cannot be ignored.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalObstetrics and Gynecology
Volume46
Issue number3
StatePublished - 1975

Fingerprint

Dinoprost
Induced Abortion
Second Pregnancy Trimester
Abortifacient Agents
Uterine Rupture
Pregnancy
Injections
Lacerations
Hematocrit
Cervix Uteri
Fistula
Dilatation
Appointments and Schedules
Anti-Bacterial Agents
Infection
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Complications following prostaglandin F2(α) induced midtrimester abortion. / Duenhoelter, J. H.; Gant, N. F.

In: Obstetrics and Gynecology, Vol. 46, No. 3, 1975, p. 247-250.

Research output: Contribution to journalArticle

Duenhoelter, JH & Gant, NF 1975, 'Complications following prostaglandin F2(α) induced midtrimester abortion', Obstetrics and Gynecology, vol. 46, no. 3, pp. 247-250.
Duenhoelter, J. H. ; Gant, N. F. / Complications following prostaglandin F2(α) induced midtrimester abortion. In: Obstetrics and Gynecology. 1975 ; Vol. 46, No. 3. pp. 247-250.
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