Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio

T. C. Andrews, D. W. Peterson, D. Doeppenschmidt, J. S. Foster, M. J. Lucca, J. A. Deering, P. J. LaVeau

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The objective of our study was to determine the rates of bleeding complications and thromboembolic events in patients receiving oral anticoagulant therapy monitored with the prothrombin time (PT) ratio versus therapy monitored with the International Normalized Ratio (INR) using a retrospective time series study design. Over 650 patients enrolled in a large anticoagulation clinic were studied during two time periods corresponding to the use of the PT ratio versus the INR to guide anticoagulant therapy, with over 400 patient-years of follow-up for each time period. The rate of bleeding complications using the PT ratio to guide therapy was 6.7% (1.2% major, 5.5% minor) per patient-year, compared with 2.9% (0% major, 2.9% minor) using the INR (p = 0.02). The rate of thromboembolic complications was as 1.0% using the PT ratio, compared with 0.2% using the INR (p=NS). Therapy monitored with the INR required 19.8 visits per year, compared with 20.7 visits per year using the PT ratio. We conclude that the INR should be used to monitor oral anticoagulant therapy in an effort to reduce bleeding complications while maintaining an acceptable late of thromboembolic events.

Original languageEnglish (US)
Pages (from-to)80-82
Number of pages3
JournalClinical Cardiology
Volume18
Issue number2
StatePublished - 1995

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International Normalized Ratio
Prothrombin Time
Warfarin
Anticoagulants
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Andrews, T. C., Peterson, D. W., Doeppenschmidt, D., Foster, J. S., Lucca, M. J., Deering, J. A., & LaVeau, P. J. (1995). Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio. Clinical Cardiology, 18(2), 80-82.

Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio. / Andrews, T. C.; Peterson, D. W.; Doeppenschmidt, D.; Foster, J. S.; Lucca, M. J.; Deering, J. A.; LaVeau, P. J.

In: Clinical Cardiology, Vol. 18, No. 2, 1995, p. 80-82.

Research output: Contribution to journalArticle

Andrews, TC, Peterson, DW, Doeppenschmidt, D, Foster, JS, Lucca, MJ, Deering, JA & LaVeau, PJ 1995, 'Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio', Clinical Cardiology, vol. 18, no. 2, pp. 80-82.
Andrews TC, Peterson DW, Doeppenschmidt D, Foster JS, Lucca MJ, Deering JA et al. Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio. Clinical Cardiology. 1995;18(2):80-82.
Andrews, T. C. ; Peterson, D. W. ; Doeppenschmidt, D. ; Foster, J. S. ; Lucca, M. J. ; Deering, J. A. ; LaVeau, P. J. / Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio. In: Clinical Cardiology. 1995 ; Vol. 18, No. 2. pp. 80-82.
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