Composite tissue allotransplantation - A new era in plastic surgery?

Shehan Hettiaratchy, Mark A. Randolph, Fraņcois Petit, W. P. Andrew Lee, Peter E.M. Butler

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Composite tissue allotransplantation (CTA) holds great potential for reconstructive surgery. The recent hand transplants have made this a clinical reality. However, concerns about CTA have divided the medical community. The current transplants require life-long immunosuppression, which could place the recipients at risk of serious complications. In addition despite potent immunosuppression, chronic rejection may still negate any early favourable results. This article will outline the clinical experience of CTA, the major problems of the technique and the potential solutions to these problems.

Original languageEnglish (US)
Pages (from-to)381-391
Number of pages11
JournalBritish Journal of Plastic Surgery
Volume57
Issue number5
DOIs
Publication statusPublished - Jul 2004
Externally publishedYes

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Keywords

  • Composite tissue transplantation
  • Immunosuppression
  • Tolerance

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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