TY - JOUR
T1 - Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome
AU - Stroud, Hume
AU - Greenberg, Maxim V.C.
AU - Feng, Suhua
AU - Bernatavichute, Yana V.
AU - Jacobsen, Steven E.
PY - 2013/1/7
Y1 - 2013/1/7
N2 - Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencing mutants by generating single-nucleotide resolution maps of DNA methylation. We find that DNA methylation is site specifically regulated by different factors. Furthermore, we have identified additional regulators of DNA methylation. These data and analyses will serve as a comprehensive community resource for further understanding the control of DNA methylation patterning.
AB - Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencing mutants by generating single-nucleotide resolution maps of DNA methylation. We find that DNA methylation is site specifically regulated by different factors. Furthermore, we have identified additional regulators of DNA methylation. These data and analyses will serve as a comprehensive community resource for further understanding the control of DNA methylation patterning.
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U2 - 10.1016/j.cell.2012.10.054
DO - 10.1016/j.cell.2012.10.054
M3 - Article
C2 - 23313553
AN - SCOPUS:84872614860
SN - 0092-8674
VL - 152
SP - 352
EP - 364
JO - Cell
JF - Cell
IS - 1-2
ER -