Comprehensive autophagy evaluation in cardiac disease models

Nina Kaludercic; Maria Chiara Maiuri; Susmita Kaushik; Álvaro F. Fernández; Jenny De Bruijn; Francesca Castoldi; Yun Chen; Jumpei Ito; Risa Mukai; Tomokazu Murakawa; Jihoon Nah; Federico Pietrocola; Toshiro Saito; Salwa Sebti; Martina Semenzato; Lorenza Tsansizi; Sebastiano Sciarretta; Julio Madrigal-Matute

doi:10.1093/cvr/cvz233

Comprehensive autophagy evaluation in cardiac disease models

Nina Kaludercic, Maria Chiara Maiuri, Susmita Kaushik, Álvaro F. Fernández, Jenny De Bruijn, Francesca Castoldi, Yun Chen, Jumpei Ito, Risa Mukai, Tomokazu Murakawa, Jihoon Nah, Federico Pietrocola, Toshiro Saito, Salwa Sebti, Martina Semenzato, Lorenza Tsansizi, Sebastiano Sciarretta, Julio Madrigal-Matute

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

Original language	English (US)
Pages (from-to)	483-504
Number of pages	22
Journal	Cardiovascular Research
Volume	116
Issue number	3
DOIs	https://doi.org/10.1093/cvr/cvz233
State	Published - Mar 1 2020

Keywords

Autophagy
Autosis
Cardiac diseases
Chaperone-mediated autophagy
Heart
Mitophagy

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1093/cvr/cvz233

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Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernández, Á. F., De Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., Nah, J., Pietrocola, F., Saito, T., Sebti, S., Semenzato, M., Tsansizi, L., Sciarretta, S., & Madrigal-Matute, J. (2020). Comprehensive autophagy evaluation in cardiac disease models. Cardiovascular Research, 116(3), 483-504. https://doi.org/10.1093/cvr/cvz233

Kaludercic, N, Maiuri, MC, Kaushik, S, Fernández, ÁF, De Bruijn, J, Castoldi, F, Chen, Y, Ito, J, Mukai, R, Murakawa, T, Nah, J, Pietrocola, F, Saito, T, Sebti, S, Semenzato, M, Tsansizi, L, Sciarretta, S & Madrigal-Matute, J 2020, 'Comprehensive autophagy evaluation in cardiac disease models', Cardiovascular Research, vol. 116, no. 3, pp. 483-504. https://doi.org/10.1093/cvr/cvz233

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abstract = "Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.",

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AU - Maiuri, Maria Chiara

AU - Kaushik, Susmita

AU - Fernández, Álvaro F.

AU - De Bruijn, Jenny

AU - Castoldi, Francesca

AU - Chen, Yun

AU - Ito, Jumpei

AU - Mukai, Risa

AU - Murakawa, Tomokazu

AU - Nah, Jihoon

AU - Pietrocola, Federico

AU - Saito, Toshiro

AU - Sebti, Salwa

AU - Semenzato, Martina

AU - Tsansizi, Lorenza

AU - Sciarretta, Sebastiano

AU - Madrigal-Matute, Julio

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N2 - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

AB - Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.

KW - Autophagy

KW - Autosis

KW - Cardiac diseases

KW - Chaperone-mediated autophagy

KW - Heart

KW - Mitophagy

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Comprehensive autophagy evaluation in cardiac disease models

Abstract

Keywords

ASJC Scopus subject areas

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