Concanavalin a increases the strength of baby hamster kidney cell attachment to substratum

Research output: Contribution to journalArticle

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Abstract

The strength of attachment of normal and transformed baby hamster kidney cells was markedly increased when attached cells were treated with concanavalin A (Con A). The cells became less sensitive to detachment by physical shear or by treatment with trypsin or EDTA; however, their morphology, as observed by phase contrast microscopy, did not change. The effects of Con A were prevented by the simultaneous addition of either Dglucose or a-methyl-n-glucoside with the Con A. Also addition of these reagents to the attached cells after Con A treatment partially reversed the effects caused by Con A. Pretreatment of the culture flasks with Con A before cell attachment resulted in an increase in the strength of cell attachment to the culture flasks as compared to untreated controls.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalJournal of Cell Biology
Volume58
Issue number3
DOIs
StatePublished - Sep 1 1973

ASJC Scopus subject areas

  • Cell Biology

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