Concentrations of antimicrobial agents in middle ear fluid, saliva and tears

John D. Nelson, Charles M. Ginsburg, Ora McLeland, Joan Clahsen, M. C. Culbertson, Henry Carder

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Antibiotic concentrations in middle ear fluid (MEF), saliva and tears were measured in children with persistent middle ear effusions undergoing tympanostomy tube placement. In 31 children given cefaclor, specimens of serum, saliva and MEF were collected at 0.5, 1, 2, 3 or 5 h after a dose. Another group of 37 children were randomized to receive a single dose of penicillin V, amoxicillin, ampicillin, erythromycin estolate, erythromycin ethyl-succinate, trimethoprim-sulfamethoxazole or cefaclor. Concentrations of antibiotics in saliva and tears bore no consistent relationship to those in MEF. Mean concentrations of all drugs in MEF were several-fold greater than the usual minimal inhibitory concentrations (MIC) of pneumococci, but only with trimethoprim and cefaclor were they greater than the usual MIC's for Haemophilus influenzae. Concentrations of antibiotics in MEF in persistent effusions were comparable to those previously reported in acute purulent effusions.

Original languageEnglish (US)
Pages (from-to)327-334
Number of pages8
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume3
Issue number4
DOIs
StatePublished - 1981

Fingerprint

Middle Ear
Anti-Infective Agents
Tears
Saliva
Cefaclor
Anti-Bacterial Agents
Erythromycin Estolate
Middle Ear Ventilation
Penicillin V
Otitis Media with Effusion
Trimethoprim
Amoxicillin
Sulfamethoxazole Drug Combination Trimethoprim
Haemophilus influenzae
Succinic Acid
Erythromycin
Ampicillin
Streptococcus pneumoniae
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Concentrations of antimicrobial agents in middle ear fluid, saliva and tears. / Nelson, John D.; Ginsburg, Charles M.; McLeland, Ora; Clahsen, Joan; Culbertson, M. C.; Carder, Henry.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 3, No. 4, 1981, p. 327-334.

Research output: Contribution to journalArticle

Nelson, John D. ; Ginsburg, Charles M. ; McLeland, Ora ; Clahsen, Joan ; Culbertson, M. C. ; Carder, Henry. / Concentrations of antimicrobial agents in middle ear fluid, saliva and tears. In: International Journal of Pediatric Otorhinolaryngology. 1981 ; Vol. 3, No. 4. pp. 327-334.
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