Concentrations of apolipoprotein A-I-containing particles in patients with hypoalphalipoproteinemia

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36 Scopus citations

Abstract

This study was performed to determine relations among concentrations of high-density lipoprotein (HDL) apolipoprotein (apo) A-I and apoA-II and lipoproteins with apoA-I only (LpA-I) and with both apoA-I and apoA-II (LpA- I:A-II) in patients with low plasma levels of HDL cholesterol. Seventy-seven middle-aged men with low HDL cholesterol levels (<40 mg/dL) were compared with 37 middle-aged men with normal HDL cholesterol levels (>40 mg/dL). Low- HDL patients were divided into those with normotriglyceridemia (triglycerides <250 mg/dL; n=49) and hypertriglyceridemia (triglycerides ≥250 mg/dL, n=28). Total apoA-I and apoA-II concentrations and apoA-I levels in LpA-I were significantly lower in the two low-HDL groups compared with control subjects. Although low-HDL patients' apoA-I levels were numerically lower in LpA-I:A- II compared with control subjects' levels, the differences were not statistically significant. Thus, there is a preferential reduction in apoA-I levels of LpA-I compared with LpA-I:A-II in patients with low HDL cholesterol. This preferential reduction in LpA-I levels was observed in both normotriglyceridemic and hypertriglyceridemic patients. However, among low- HDL patients levels of apoA-I in LpA-I did not distinguish between those with and without coronary heart disease.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalArteriosclerosis and Thrombosis
Volume14
Issue number4
DOIs
StatePublished - 1994

Keywords

  • HDL
  • apoA-I
  • lipoproteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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