Concentrations of apolipoprotein A-I-containing particles in patients with hypoalphalipoproteinemia

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Abstract

This study was performed to determine relations among concentrations of high-density lipoprotein (HDL) apolipoprotein (apo) A-I and apoA-II and lipoproteins with apoA-I only (LpA-I) and with both apoA-I and apoA-II (LpA-I:A-II) in patients with low plasma levels of HDL cholesterol. Seventy-seven middle-aged men with low HDL cholesterol levels (<40 mg/dL) were compared with 37 middle-aged men with normal HDL cholesterol levels (>40 mg/dL). Low-HDL patients were divided into those with normotriglyceridemia (triglycerides <250 mg/dL; n=49) and hypertriglyceridemia (triglycerides ≥250 mg/dL; n=28). Total apoA-I and apoA-II concentrations and apoA-I levels in LpA-I were significantly lower in the two low-HDL groups compared with control subjects. Although low-HDL patients' apoA-I levels were numerically lower in LpA-I:A-II compared with control subjects' levels, the differences were not statistically significant. Thus, there is a preferential reduction in apoA-I levels of LpA-I compared with LpA-I:A-II in patients with low HDL cholesterol. This preferential reduction in LpA-I levels was observed in both normotriglyceridemic and hypertriglyceridemic patients. However, among low-HDL patients levels of apoA-I in LpA-I did not distinguish between those with and without coronary heart disease.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume14
Issue number4
StatePublished - 1994

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Hypoalphalipoproteinemias
Apolipoprotein A-I
Lipoproteins
HDL Lipoproteins
Apolipoprotein A-II
LDL Lipoproteins
HDL Cholesterol
LDL Cholesterol
Triglycerides

Keywords

  • ApoA-I
  • HDL
  • Lipoproteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "This study was performed to determine relations among concentrations of high-density lipoprotein (HDL) apolipoprotein (apo) A-I and apoA-II and lipoproteins with apoA-I only (LpA-I) and with both apoA-I and apoA-II (LpA-I:A-II) in patients with low plasma levels of HDL cholesterol. Seventy-seven middle-aged men with low HDL cholesterol levels (<40 mg/dL) were compared with 37 middle-aged men with normal HDL cholesterol levels (>40 mg/dL). Low-HDL patients were divided into those with normotriglyceridemia (triglycerides <250 mg/dL; n=49) and hypertriglyceridemia (triglycerides ≥250 mg/dL; n=28). Total apoA-I and apoA-II concentrations and apoA-I levels in LpA-I were significantly lower in the two low-HDL groups compared with control subjects. Although low-HDL patients' apoA-I levels were numerically lower in LpA-I:A-II compared with control subjects' levels, the differences were not statistically significant. Thus, there is a preferential reduction in apoA-I levels of LpA-I compared with LpA-I:A-II in patients with low HDL cholesterol. This preferential reduction in LpA-I levels was observed in both normotriglyceridemic and hypertriglyceridemic patients. However, among low-HDL patients levels of apoA-I in LpA-I did not distinguish between those with and without coronary heart disease.",
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N2 - This study was performed to determine relations among concentrations of high-density lipoprotein (HDL) apolipoprotein (apo) A-I and apoA-II and lipoproteins with apoA-I only (LpA-I) and with both apoA-I and apoA-II (LpA-I:A-II) in patients with low plasma levels of HDL cholesterol. Seventy-seven middle-aged men with low HDL cholesterol levels (<40 mg/dL) were compared with 37 middle-aged men with normal HDL cholesterol levels (>40 mg/dL). Low-HDL patients were divided into those with normotriglyceridemia (triglycerides <250 mg/dL; n=49) and hypertriglyceridemia (triglycerides ≥250 mg/dL; n=28). Total apoA-I and apoA-II concentrations and apoA-I levels in LpA-I were significantly lower in the two low-HDL groups compared with control subjects. Although low-HDL patients' apoA-I levels were numerically lower in LpA-I:A-II compared with control subjects' levels, the differences were not statistically significant. Thus, there is a preferential reduction in apoA-I levels of LpA-I compared with LpA-I:A-II in patients with low HDL cholesterol. This preferential reduction in LpA-I levels was observed in both normotriglyceridemic and hypertriglyceridemic patients. However, among low-HDL patients levels of apoA-I in LpA-I did not distinguish between those with and without coronary heart disease.

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