Concise review: Adipose-derived stromal cells for skeletal regenerative medicine

Benjamin Levi, Michael T. Longaker

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations

Abstract

As the average age of the population grows, the incidence of osteoporosis and skeletal diseases continues to rise. Current treatment options for skeletal repair include immobilization, rigid fixation, alloplastic materials, and bone grafts, all which have significant limitations, especially in the elderly. Adipose-derived stromal cells (ASCs) represent a readily available abundant supply of mesenchymal stem cells, which demonstrate the ability to undergo osteogenesis in vitro and in vivo, making ASCs a promising source of skeletal progenitor cells. Current protocols allow for the harvest of over one million cells from only 15 ml of lipoaspirate. Despite the clinical use of ASCs to treat systemic inflammatory diseases, no large human clinical trials exist using ASCs for skeletal tissue engineering. The aim of this review is to define ASCs, to describe the isolation procedure of ASCs, to review the basic biology of their osteogenic differentiation, discuss cell types and scaffolds available for bone tissue engineering, and finally, to explore imaging of ASCs and their potential future role in human skeletal tissue engineering efforts.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalSTEM CELLS
Volume29
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • Adipogenic differentiation
  • Adipose-derived stromal cells
  • Multipotent stromal cells
  • Skeletal tissue engineering
  • Subcutaneous fat depots
  • Tissue regeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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